For any chemist or researcher involved in advanced organic synthesis, a thorough understanding of a chemical's properties is fundamental to its effective and safe utilization. 1,1-Dibromo-3,3,3-trifluoroacetone (CAS 431-67-4) is a potent and versatile fluorinated compound that plays a significant role in the synthesis of pharmaceutical intermediates and other fine chemicals. Its unique structure imparts specific reactivity that makes it a valuable, yet sometimes challenging, reagent.

At its core, 1,1-Dibromo-3,3,3-trifluoroacetone is characterized by its molecular formula, C3HBr2F3O, and a molecular weight of approximately 269.84 g/mol. This relatively small molecule packs a significant punch due to the presence of electronegative halogens and the trifluoromethyl group. Physically, it is often described as a light-orange liquid, though some sources may list it as a liquid with a color ranging from colorless to red or green depending on purity and handling. Its density is typically around 2.188 g/cm³ at 20°C, indicating it is significantly denser than water.

The boiling point of 1,1-Dibromo-3,3,3-trifluoroacetone falls within the range of 111-113°C at standard atmospheric pressure. This moderate boiling point allows for its purification via distillation, a common practice for industrial-scale supply. Its solubility is primarily in organic solvents like chloroform, with limited miscibility or difficulty mixing in water, which is a typical characteristic for highly halogenated organic compounds.

The chemical reactivity of 1,1-Dibromo-3,3,3-trifluoroacetone is largely dictated by the electron-withdrawing nature of the trifluoromethyl group and the labile bromine atoms. This electron deficiency makes the carbonyl carbon highly electrophilic, prone to nucleophilic attack. The bromine atoms can also be displaced under certain conditions, facilitating carbon-carbon bond formation or further functionalization. The compound is known to undergo basic hydrolysis, reacting to form trifluoropyruvaldehyde hydrate, which itself is a valuable synthetic intermediate.

Safety considerations are paramount when handling this chemical. Hazard statements like H314 (Causes severe skin burns and eye damage) and H318 (Causes serious eye damage) underscore its corrosive nature. Therefore, strict adherence to safety protocols, including the use of appropriate personal protective equipment (PPE) such as gloves, eye protection, and respiratory protection, is essential. When sourcing this chemical, it is crucial to obtain it from reputable manufacturers who provide comprehensive Safety Data Sheets (SDS) detailing all necessary handling, storage, and emergency procedures. Purchasing from a reliable supplier in China ensures that you receive a product with the correct safety information readily available.

Understanding these physical and chemical properties is vital for chemists planning synthetic routes, optimizing reaction conditions, and ensuring safe laboratory practices. Whether you are a purchasing manager looking to buy 1,1-Dibromo-3,3,3-trifluoroacetone or a research scientist designing a new synthesis, a clear grasp of its characteristics will lead to more successful and efficient outcomes.