For chemists and R&D professionals, a deep understanding of a chemical intermediate's properties is crucial for successful synthesis design. 2-Fluoro-3-nitrobenzoic Acid (CAS: 317-46-4) is a prime example of a compound whose chemical characteristics make it an invaluable building block in organic synthesis. Its unique combination of functional groups dictates its reactivity, stability, and applicability across industries like pharmaceuticals, agrochemicals, and dyes. As a dedicated supplier, we aim to provide not just the material, but also insights into its chemical behavior.

Key Chemical Characteristics and Reactivity

2-Fluoro-3-nitrobenzoic Acid presents a fascinating interplay of electronic effects due to its substituents:

  • Acidity: The presence of the electron-withdrawing nitro group and the electronegative fluorine atom significantly increases the acidity of the carboxylic acid group compared to benzoic acid. This enhanced acidity can influence reaction conditions and the choice of reagents. The predicted pKa is around 2.32, indicating a strong acid.
  • Reactivity of the Carboxyl Group: Like other carboxylic acids, the carboxyl group can undergo typical transformations. It can be readily converted into acyl chlorides using reagents like thionyl chloride, esterified with alcohols, or reduced to the corresponding benzyl alcohol. These reactions are fundamental steps in building more complex molecules.
  • Aromatic Nucleophilic Substitution: The strong electron-withdrawing nature of both the nitro group and the fluorine atom activates the aromatic ring towards nucleophilic aromatic substitution (SNAr). The fluorine atom, being a good leaving group in such reactions, can be displaced by various nucleophiles under appropriate conditions, allowing for the introduction of new functional groups onto the aromatic ring. This is a key reaction pathway for synthesizing many derivatives.
  • Stability and Storage: Typically supplied as a solid, 2-Fluoro-3-nitrobenzoic Acid is generally stable under recommended storage conditions. Sources often recommend storing it in a cool, dry place, away from incompatible materials, and keeping the container tightly closed. Its hygroscopic nature means protection from moisture is important. Many recommend refrigeration at 2-8°C for optimal long-term stability.

Applications Driven by Chemical Properties

These chemical properties directly translate into its widespread use as an intermediate:

  • In pharmaceutical synthesis, its reactivity allows for the introduction of specific functionalities required for drug activity.
  • In agrochemical development, these transformations are key to creating pesticides and herbicides with targeted modes of action.
  • In the dye industry, the aromatic system and substituent effects can be manipulated to achieve desired color properties and fastness.

When researchers and procurement specialists search for this compound, they might use terms like '2-fluoro-3-nitrobenzoic acid chemical properties,' 'CAS 317-46-4 synthesis,' or 'buy organic synthesis intermediate.' Understanding these properties empowers chemists to design efficient and effective synthetic routes, ensuring successful project outcomes. As your trusted chemical supplier, we ensure the quality and consistency of 2-Fluoro-3-nitrobenzoic Acid, providing a reliable foundation for your synthesis endeavors.