For chemists and researchers engaged in synthetic organic chemistry, a thorough understanding of intermediate properties is fundamental to designing efficient reaction pathways. 4-Trifluoromethylbenzoic Anhydride (CAS: 25753-16-6) is a prime example of a compound whose chemical characteristics dictate its broad utility. This article explores the key properties of this valuable intermediate, highlighting why sourcing it from a reliable manufacturer is crucial.

At its core, 4-Trifluoromethylbenzoic Anhydride is an acid anhydride derived from 4-(trifluoromethyl)benzoic acid. Its structure features two 4-trifluoromethylbenzoyl groups linked by an oxygen atom, forming a highly reactive functional group. The electron-withdrawing nature of the trifluoromethyl (-CF3) substituent significantly influences the reactivity of the aromatic ring and the anhydride linkage. This makes it an effective acylating agent, readily reacting with nucleophiles such as alcohols and amines to form esters and amides, respectively. The typical appearance is a white to off-white crystalline powder, indicating a solid form at room temperature with a melting point generally in the range of 127-131°C, as reported in various chemical databases.

The moisture sensitivity of acid anhydrides is a notable characteristic, and 4-Trifluoromethylbenzoic Anhydride is no exception. Exposure to moisture can lead to hydrolysis, reverting it to the parent carboxylic acid. Therefore, proper storage under an inert atmosphere and in tightly sealed containers is essential to maintain its integrity and reactivity. This characteristic underscores the importance of purchasing from a supplier that handles and packages its chemicals with care.

NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer and supplier of 4-Trifluoromethylbenzoic Anhydride in China, committed to providing products with a purity of ≥98.0%. Our quality control measures ensure that the intermediate you receive is stable and effective for your synthetic needs. If you are looking to buy this compound and require detailed specifications or technical support, we are your go-to partner. Contact us for inquiries about pricing and bulk orders; we are ready to assist you in securing this vital reagent for your laboratory or production facility.