Understanding the Chemical Properties of 5-Bromo-3-ethynylpyridin-2-amine (CAS 1210838-82-6)
In the realm of synthetic chemistry, understanding the detailed properties of key intermediates is fundamental to successful project execution. 5-Bromo-3-ethynylpyridin-2-amine, identified by its CAS number 1210838-82-6 and molecular formula C7H5BrN2, is a heterocyclic compound of significant interest. Its molecular weight of 197.03200 provides a basic parameter for stoichiometric calculations in chemical reactions.
The structure of 5-bromo-3-ethynylpyridin-2-amine is central to its reactivity. It features a pyridine ring, which is an aromatic heterocycle known for its electron-deficient nature. Attached to this ring are three key functional groups: a bromine atom at the 5-position, an ethynyl (alkyne) group at the 3-position, and an amine group (-NH2) at the 2-position. Each of these groups imparts specific chemical behaviors.
The bromine atom is a good leaving group, making the compound susceptible to nucleophilic aromatic substitution under certain conditions, but more commonly, it is utilized in palladium-catalyzed cross-coupling reactions. These reactions, such as the Suzuki-Miyaura coupling (with boronic acids) or the Sonogashira coupling (with terminal alkynes), are indispensable tools for forming new carbon-carbon bonds, allowing for the construction of complex molecular architectures. This is a critical pathway for chemists when they aim to buy 5-bromo-3-ethynylpyridin-2-amine for their synthesis needs.
The ethynyl group, a terminal alkyne, is highly versatile. It can undergo various addition reactions, cycloadditions (like the click chemistry azide-alkyne cycloaddition), and can also be involved in further coupling reactions. Its presence adds another layer of synthetic flexibility, allowing for the introduction of diverse functionalities or the creation of conjugated systems, which are important in materials science and medicinal chemistry.
The amine group (-NH2) at the 2-position is a nucleophilic site and can be readily acylated, alkylated, or undergo condensation reactions. This group can also influence the electronic properties of the pyridine ring and participate in hydrogen bonding, which is relevant in supramolecular chemistry and biological interactions.
For researchers and chemical manufacturers seeking this compound, NINGBO INNO PHARMCHEM CO.,LTD. offers reliable access to 5-bromo-3-ethynylpyridin-2-amine. Understanding these chemical properties is key to effectively utilizing this intermediate in projects ranging from pharmaceutical research to the development of new materials. By providing access to such well-characterized intermediates, NINGBO INNO PHARMCHEM CO.,LTD. supports the advancement of chemical sciences.
The structure of 5-bromo-3-ethynylpyridin-2-amine is central to its reactivity. It features a pyridine ring, which is an aromatic heterocycle known for its electron-deficient nature. Attached to this ring are three key functional groups: a bromine atom at the 5-position, an ethynyl (alkyne) group at the 3-position, and an amine group (-NH2) at the 2-position. Each of these groups imparts specific chemical behaviors.
The bromine atom is a good leaving group, making the compound susceptible to nucleophilic aromatic substitution under certain conditions, but more commonly, it is utilized in palladium-catalyzed cross-coupling reactions. These reactions, such as the Suzuki-Miyaura coupling (with boronic acids) or the Sonogashira coupling (with terminal alkynes), are indispensable tools for forming new carbon-carbon bonds, allowing for the construction of complex molecular architectures. This is a critical pathway for chemists when they aim to buy 5-bromo-3-ethynylpyridin-2-amine for their synthesis needs.
The ethynyl group, a terminal alkyne, is highly versatile. It can undergo various addition reactions, cycloadditions (like the click chemistry azide-alkyne cycloaddition), and can also be involved in further coupling reactions. Its presence adds another layer of synthetic flexibility, allowing for the introduction of diverse functionalities or the creation of conjugated systems, which are important in materials science and medicinal chemistry.
The amine group (-NH2) at the 2-position is a nucleophilic site and can be readily acylated, alkylated, or undergo condensation reactions. This group can also influence the electronic properties of the pyridine ring and participate in hydrogen bonding, which is relevant in supramolecular chemistry and biological interactions.
For researchers and chemical manufacturers seeking this compound, NINGBO INNO PHARMCHEM CO.,LTD. offers reliable access to 5-bromo-3-ethynylpyridin-2-amine. Understanding these chemical properties is key to effectively utilizing this intermediate in projects ranging from pharmaceutical research to the development of new materials. By providing access to such well-characterized intermediates, NINGBO INNO PHARMCHEM CO.,LTD. supports the advancement of chemical sciences.
Perspectives & Insights
Logic Thinker AI
“In the realm of synthetic chemistry, understanding the detailed properties of key intermediates is fundamental to successful project execution.”
Molecule Spark 2025
“5-Bromo-3-ethynylpyridin-2-amine, identified by its CAS number 1210838-82-6 and molecular formula C7H5BrN2, is a heterocyclic compound of significant interest.”
Alpha Pioneer 01
“03200 provides a basic parameter for stoichiometric calculations in chemical reactions.”