For chemists, researchers, and procurement specialists, a thorough understanding of a chemical intermediate's properties is fundamental to its successful application. Ethyl 5,7-difluoro-1H-indole-2-carboxylate (CAS: 220679-10-7) is a prime example of a fine chemical intermediate whose specific characteristics dictate its utility in organic synthesis, particularly in the pharmaceutical sector.

Key Physical and Chemical Characteristics

This compound, commonly supplied as a white powder, exhibits a range of properties that are critical for handling, storage, and reaction planning. Here's a breakdown of its significant attributes:

  • Appearance: White powder, indicating a solid form at room temperature.
  • Purity (Assay): Typically specified as ≥97.0%, ensuring a high level of the desired compound for chemical reactions.
  • Molecular Formula: C11H9F2NO2, detailing the atomic composition.
  • Molecular Weight: 225.191 g/mol, important for stoichiometric calculations in synthesis.
  • Density: Approximately 1.4±0.1 g/cm³, providing insight into its mass per unit volume.
  • Boiling Point: 342.5±37.0 °C at 760 mmHg. This high boiling point suggests thermal stability under moderate conditions.
  • Flash Point: 160.9±26.5 °C, indicating the temperature at which it can vaporize to form an ignitable mixture with air, crucial for safety assessments.
  • Vapor Pressure: A low 0.0±0.8 mmHg at 25°C, implying minimal volatility and suitability for controlled environments.
  • Index of Refraction: 1.581, a property that can be relevant in certain spectroscopic or analytical applications.

Implications for Handling and Application

These properties inform critical decisions for both laboratory research and industrial production. The white powder form and low volatility simplify handling and storage compared to liquid or gaseous reagents. The relatively high flash point requires caution but is manageable with standard laboratory safety protocols. The high purity is essential for its role as an intermediate in organic synthesis, particularly when building complex pharmaceutical molecules where side reactions must be minimized.

Sourcing from Reliable Manufacturers

When sourcing Ethyl 5,7-difluoro-1H-indole-2-carboxylate, it is paramount to engage with manufacturers and suppliers who can provide accurate and verifiable property data. Companies specializing in fine chemicals, often based in regions like China with strong chemical manufacturing capabilities, can deliver this intermediate with the required purity and documented specifications. Understanding these chemical properties empowers chemists and procurement specialists to make informed decisions, ensuring efficient synthesis and successful product development.