For any chemist or formulator working with 2,6-Dichloropurine (CAS 5451-40-1), a thorough understanding of its chemical properties, along with proper handling and storage procedures, is crucial for successful and safe utilization. As a leading supplier of pharmaceutical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing our clients with the necessary information to work effectively with our products.

Chemical Identity and Structure: 2,6-Dichloropurine, with the molecular formula C5H2Cl2N4 and a molecular weight of 189.00 g/mol, is characterized by a purine core substituted with chlorine atoms at the 2 and 6 positions. Its CAS number is 5451-40-1. This specific structure dictates its reactivity and applications, particularly in organic synthesis.

Physical Properties: Typically, 2,6-Dichloropurine appears as a white to light yellow crystalline powder. Its melting point is reported in the range of 185-195°C (with decomposition). Solubility is a key characteristic for synthetic chemists; it is generally soluble in polar organic solvents such as DMSO, hot ethanol, and hot methanol, but sparingly soluble in water. These properties are vital for designing appropriate reaction conditions and purification methods.

Reactivity and Applications: The chlorine atoms on the purine ring are labile and can be readily displaced by various nucleophiles, such as amines, alkoxides, or thiolates. This makes 2,6-Dichloropurine an invaluable intermediate for synthesizing diverse purine derivatives. Its primary use is in the pharmaceutical industry, serving as a building block for nucleoside and nucleotide analogs, which are critical components in antiviral and anticancer drug development. Researchers looking to buy this compound for synthesis will find its reactive nature highly advantageous.

Safety and Handling: As with many fine chemicals, 2,6-Dichloropurine should be handled with appropriate precautions. It is classified as an irritant and may be harmful if swallowed, inhaled, or absorbed through the skin. When working with this material, it is recommended to wear personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated area or under a fume hood. Storage should be in a cool, dry place, away from incompatible materials. NINGBO INNO PHARMCHEM CO.,LTD. provides detailed Safety Data Sheets (SDS) for all our products, which should be consulted before handling.

Understanding these properties is essential for any scientist or procurement manager intending to purchase 2,6-Dichloropurine. NINGBO INNO PHARMCHEM CO.,LTD. is committed to supplying high-quality products and the supporting information needed for their safe and effective application in your research and manufacturing processes.