Understanding the Chemical Properties and Synthesis of 4-Fluoroisoquinoline
4-Fluoroisoquinoline, identified by CAS number 394-67-2, is a chemical compound with a molecular formula of C9H6FN and a molecular weight of 147.15 g/mol. This compound typically appears as a white to light yellow powder and possesses a melting point of 34°C. Its boiling point is recorded at 240°C, with a flash point of 99°C. These physical and chemical properties make it a valuable reagent for various scientific applications.
The synthesis of 4-Fluoroisoquinoline is a critical process, often involving multi-step organic reactions. A common route described in literature involves the reaction of 4-bromoisoquinoline with n-butyllithium at low temperatures, followed by treatment with an N-fluorobenzenesulfonimide. This method, when optimized, can yield 4-Fluoroisoquinoline in good quantities. The successful synthesis relies on precise control of reaction conditions and careful purification techniques to achieve the desired high purity, often above 98%.
The primary usage of 4-Fluoroisoquinoline is as a research chemical and as a key intermediate in the synthesis of more complex molecules. Its strategic placement of a fluorine atom on the isoquinoline ring system makes it particularly useful in medicinal chemistry. Fluorine substitution can often enhance drug efficacy, improve metabolic stability, and alter pharmacokinetic profiles. Therefore, 4-Fluoroisoquinoline serves as a vital building block for pharmaceutical intermediates, contributing to the development of new therapeutic agents.
For companies looking to procure this compound, understanding its synthesis and properties is essential for quality assurance. Sourcing from reputable manufacturers, especially those based in China, ensures access to well-characterized material. The availability of detailed information on its chemical structure, synthesis, and purity levels supports its application in demanding research and industrial settings, making it a cornerstone for innovation in the chemical industry.
The synthesis of 4-Fluoroisoquinoline is a critical process, often involving multi-step organic reactions. A common route described in literature involves the reaction of 4-bromoisoquinoline with n-butyllithium at low temperatures, followed by treatment with an N-fluorobenzenesulfonimide. This method, when optimized, can yield 4-Fluoroisoquinoline in good quantities. The successful synthesis relies on precise control of reaction conditions and careful purification techniques to achieve the desired high purity, often above 98%.
The primary usage of 4-Fluoroisoquinoline is as a research chemical and as a key intermediate in the synthesis of more complex molecules. Its strategic placement of a fluorine atom on the isoquinoline ring system makes it particularly useful in medicinal chemistry. Fluorine substitution can often enhance drug efficacy, improve metabolic stability, and alter pharmacokinetic profiles. Therefore, 4-Fluoroisoquinoline serves as a vital building block for pharmaceutical intermediates, contributing to the development of new therapeutic agents.
For companies looking to procure this compound, understanding its synthesis and properties is essential for quality assurance. Sourcing from reputable manufacturers, especially those based in China, ensures access to well-characterized material. The availability of detailed information on its chemical structure, synthesis, and purity levels supports its application in demanding research and industrial settings, making it a cornerstone for innovation in the chemical industry.
Perspectives & Insights
Nano Explorer 01
“Fluorine substitution can often enhance drug efficacy, improve metabolic stability, and alter pharmacokinetic profiles.”
Data Catalyst One
“Therefore, 4-Fluoroisoquinoline serves as a vital building block for pharmaceutical intermediates, contributing to the development of new therapeutic agents.”
Chem Thinker Labs
“For companies looking to procure this compound, understanding its synthesis and properties is essential for quality assurance.”