For chemists and researchers engaged in pharmaceutical synthesis, understanding the detailed properties of key intermediates is fundamental. This article delves into the chemical characteristics of 4-Chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine (CAS: 16372-08-0), a compound of significant importance as a precursor for the Janus kinase (JAK) inhibitor, Ruxolitinib. We will examine its physical attributes, molecular structure, and the typical specifications that scientists and buyers should look for when sourcing this material, particularly from manufacturers offering competitive pricing.

The molecular formula of 4-Chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine is C6H4ClN3, with a molecular weight of 153.569 g/mol. Its structure features a fused pyrrolo[2,3-d]pyrimidine ring system, functionalized with a chlorine atom, making it a reactive site for subsequent chemical transformations. In its pure form, this intermediate is commonly described as an off-white powder, a visual indicator of its typical quality. Reputable suppliers, often based in China, will list an assay of ≥97.0%, which is a critical parameter for ensuring the efficiency and yield of the Ruxolitinib synthesis pathway. Understanding these specifications is key for any scientist looking to buy this product for their research or development projects.

The physical and chemical properties, such as a density of approximately 1.5±0.1 g/cm³ and a boiling point of 311.9°C at 760 mmHg, provide further insights into handling and processing this compound. While these specific metrics are indicative, the most critical aspect for a buyer is the purity and consistency of the product. When you search to purchase 4-Chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine, verifying that the supplier can provide detailed technical data and a reliable Certificate of Analysis is crucial. This ensures that the material is suitable for its intended pharmaceutical application and that you are obtaining value for money from your supplier.

The role of this compound as an intermediate for Ruxolitinib places it in high demand within the pharmaceutical industry. Consequently, sourcing from manufacturers who specialize in heterocyclic intermediates and have robust production capabilities is advisable. Companies that manufacture APIs often look for strategic partnerships with chemical suppliers that can guarantee consistent quality and competitive prices for materials like 4-Chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine. If your R&D or production requires this intermediate, contacting a well-established supplier in China for a quote is a practical step towards securing your supply chain and ensuring project success.

In essence, a thorough understanding of the chemical identity and specifications of 4-Chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine is vital for effective procurement and successful synthesis. By prioritizing quality and partnering with reliable manufacturers, researchers and production teams can confidently integrate this intermediate into their workflows.