For professionals in the chemical and pharmaceutical industries, a deep understanding of the properties of key intermediates is fundamental to successful synthesis and product development. 2-Chloro-6-fluorobenzaldehyde, identified by its CAS number 387-45-1, is a compound whose chemical and physical characteristics make it an invaluable building block. This article aims to provide a clear overview of these properties, aiding researchers and procurement specialists when they consider purchasing or sourcing this intermediate.

Physically, 2-Chloro-6-fluorobenzaldehyde is typically described as a white to off-white crystalline solid or powder. Its appearance is a key initial indicator of purity, and manufacturers often provide detailed specifications regarding color and form. The compound has a defined melting point, generally reported in the range of 32-35 °C. This relatively low melting point is important for handling and processing, particularly in reactions that may involve elevated temperatures.

Chemically, the molecule’s structure is its most significant feature. It is a substituted benzaldehyde, meaning it possesses an aldehyde functional group (-CHO) attached to a benzene ring. The benzene ring is further substituted with a chlorine atom at the 2-position and a fluorine atom at the 6-position. This specific arrangement of halogens influences the molecule's reactivity and electronic properties. The electron-withdrawing nature of chlorine and fluorine atoms can affect the reactivity of the aldehyde group and the aromatic ring itself, making it suitable for a variety of synthetic transformations.

One of the most important reactions associated with 2-Chloro-6-fluorobenzaldehyde is the Knoevenagel condensation, often catalyzed by bases like piperidine. In this reaction, the aldehyde reacts with compounds containing active methylene groups, such as methyl cyanoacetate, to form new carbon-carbon bonds, leading to the synthesis of substituted propenoates. This reaction is foundational for creating more complex organic molecules, including intermediates for pharmaceuticals and specialty chemicals. Buyers seeking such versatile intermediates should confirm the compound's suitability for their intended reactions with their supplier.

Furthermore, understanding the compound's molecular formula (C7H4ClFO) and molecular weight (158.557 g/mol) is essential for stoichiometric calculations in chemical synthesis. Safety data, including hazard codes (like Xi for irritant) and recommended safety statements, are also critical information provided by manufacturers. When sourcing 2-Chloro-6-fluorobenzaldehyde, always consult the Safety Data Sheet (SDS) provided by the supplier. This detailed information empowers chemists and buyers to handle and utilize the compound safely and effectively, ensuring both research integrity and operational safety.