At NINGBO INNO PHARMCHEM CO.,LTD., we believe that a deep understanding of raw materials is key to successful product development. Copovidone VA64, a synthetic copolymer, exemplifies this, offering a remarkable blend of properties that make it indispensable across various industries, most notably pharmaceuticals. This article delves into the fundamental aspects of Copovidone VA64, from its chemical nature to its broad spectrum of applications.

Chemically, Copovidone VA64 is a random copolymer composed of N-vinylpyrrolidone and vinyl acetate in a specific ratio (typically 6:4). This composition imbues it with characteristics that bridge the gap between highly hydrophilic polymers and more hydrophobic ones. Physically, it typically presents as a white to slightly yellowish, free-flowing powder with a faint odor. Its solubility profile is noteworthy: readily dissolving in hydrophilic solvents like water, ethanol, and isopropanol, while exhibiting limited solubility in non-polar solvents.

The manufacturing of Copovidone VA64 involves free-radical polymerization, a well-established chemical process. NINGBO INNO PHARMCHEM CO.,LTD. sources Copovidone VA64 produced under stringent quality controls, ensuring purity and consistency. Its K-value, a measure of its molecular weight and solution viscosity, typically falls within a range that is optimal for its intended applications, such as binding and film formation in tablets. The specific K-value influences its performance in direct compression and wet granulation, making selection based on application needs crucial.

In the pharmaceutical sector, Copovidone VA64 is a cornerstone excipient. Its primary role as a tablet binder is well-documented, contributing to tablet hardness, reducing lamination and capping, and improving overall compressibility. This makes it ideal for both direct compression and wet granulation processes. Additionally, its film-forming capabilities are leveraged in tablet coatings, providing aesthetic appeal and protective qualities. The excipient is also fundamental in creating amorphous solid dispersions for enhancing the solubility and bioavailability of poorly water-soluble drugs, often utilizing techniques like hot melt extrusion.

Beyond pharmaceuticals, Copovidone VA64 finds applications in cosmetics as a film former and thickener, and in industrial uses like adhesives and printing inks. NINGBO INNO PHARMCHEM CO.,LTD. prides itself on offering high-purity Copovidone VA64 that meets the rigorous standards of these diverse sectors. Our commitment to quality and technical support ensures that our clients can effectively integrate this versatile polymer into their formulations to achieve optimal product performance and efficacy.