The landscape of pharmaceutical research is constantly seeking novel molecules that can unlock new therapeutic pathways. Among these, compounds that precisely modulate cellular signaling pathways are of immense interest. CPI-444, also known by its chemical name Ciforadenant, is a prime example of such a molecule, renowned for its potent and selective antagonism of the Adenosine A2A receptor (A2AR). As a key pharmaceutical intermediate, it plays a crucial role in research focused on inflammation, immunology, and oncology.

The Adenosine A2A receptor is a G protein-coupled receptor that plays a complex role in various physiological processes, including immune modulation and neurotransmission. In the context of cancer, A2A receptors are often overexpressed in the tumor microenvironment, contributing to immune suppression. By blocking these receptors, CPI-444 helps to restore anti-tumor immune responses, making it a significant target for therapeutic development.

For researchers and procurement managers in the pharmaceutical industry, understanding the technical specifications of CPI-444 is essential. Typically supplied as a white to light yellow powder with a purity of 98%, this compound offers the reliability needed for scientific experimentation. The chemical structure, characterized by its Triazolo-pyramidine core, positions it as a valuable building block for chemists synthesizing more complex molecules or studying structure-activity relationships.

When it comes to purchasing CPI-444, identifying reliable manufacturers and suppliers is paramount. NINGBO INNO PHARMCHEM CO.,LTD., a prominent chemical supplier in China, offers this compound, ensuring quality and availability for global research needs. Their ability to supply CPI-444 at competitive prices makes it accessible for various research projects, from academic laboratories to large pharmaceutical companies looking to buy in bulk.

The research applications for CPI-444 are diverse. Its primary use is in studies investigating the role of A2A receptors in disease pathogenesis and in evaluating the efficacy of A2A antagonists as potential therapeutics. This includes exploring its impact on immune cell function, inflammatory responses, and its synergistic effects when combined with other immunotherapies. The consistent availability of high-purity CPI-444 from reputable suppliers like NINGBO INNO PHARMCHEM CO.,LTD. is fundamental to advancing these critical research areas.

In conclusion, CPI-444 (Ciforadenant) is a vital pharmaceutical intermediate with significant potential in advancing research, particularly in oncology and immunology. Its specific mechanism of action as an A2A receptor antagonist makes it a compound of interest for drug discovery programs. By sourcing this Triazolo-pyramidine derivative from trusted manufacturers in China, researchers can ensure the quality and reliability of their scientific endeavors, propelling forward the development of next-generation therapies.