Cyclopamine, identified by CAS number 4449-51-8, is a fascinating steroidal alkaloid with a significant impact on biological research, particularly in the fields of developmental biology and oncology. Its unique chemical structure and potent biological activity have made it an indispensable tool for scientists worldwide.

Chemically, Cyclopamine is characterized by its complex steroidal framework. It appears as a white crystalline solid, exhibiting moderate solubility in organic solvents like DMSO and ethanol, which is crucial for its formulation in various experimental settings. Its molecular weight and formula (C27H41NO2) are well-defined, ensuring consistent product quality for research purposes.

The primary application of Cyclopamine lies in its role as a potent inhibitor of the Hedgehog (Hh) signaling pathway. This pathway is fundamental to embryonic development, controlling cell growth, differentiation, and patterning. However, its dysregulation is linked to various congenital abnormalities and cancers. Cyclopamine's ability to block this pathway makes it invaluable for studying these processes.

In developmental biology, Cyclopamine is known for its teratogenic effects, which were among the first observed properties, leading to conditions like cyclopia. This characteristic, while demonstrating its potency, also makes it a critical compound for understanding normal embryonic morphogenesis and the mechanisms behind certain birth defects. For researchers aiming to purchase Cyclopamine for such studies, it is essential to source from a reputable supplier who can guarantee purity and accurate characterization.

Beyond developmental research, Cyclopamine has garnered significant attention for its anti-cancer properties. It targets cancer stem cells and has shown promise in inhibiting the growth of various tumors, including glioblastoma and pancreatic cancer. Its mechanism as a Smoothened antagonist makes it a key player in the development of targeted cancer therapies. As a leading manufacturer of Cyclopamine in China, we offer this vital research chemical at competitive prices, ensuring accessibility for the scientific community. If you require a reliable order for CAS 4449-51-8, our streamlined procurement process guarantees efficient delivery.