Understanding Dapagliflozin Synthesis: The Role of (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
The pharmaceutical industry is constantly seeking efficient and reliable methods to synthesize complex Active Pharmaceutical Ingredients (APIs). Dapagliflozin, a groundbreaking SGLT2 inhibitor widely used for managing type 2 diabetes, is no exception. At the heart of its improved synthesis lies a critical intermediate: (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone, identified by its CAS number 461432-22-4.
For procurement managers and R&D scientists in the pharmaceutical sector, understanding the significance of this intermediate is paramount. It's not just another chemical; it's a building block that directly impacts the quality, yield, and cost-effectiveness of Dapagliflozin production. As a leading manufacturer and supplier of fine chemical intermediates, we are dedicated to providing this compound with exceptional purity and consistency, meeting the stringent demands of API synthesis.
Why is (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone so important?
This specialized benzophenone derivative serves as a key precursor in several patented synthesis routes for Dapagliflozin. Its specific chemical structure, featuring bromine and chlorine substituents on one phenyl ring and an ethoxy group on the other, is precisely what is required to efficiently build the complex molecular architecture of Dapagliflozin. The purity of this intermediate is directly correlated to the purity of the final API. Impurities present in the intermediate can carry through the synthesis process, leading to lower yields, the need for costly purification steps, or even the failure to meet regulatory standards.
Sourcing Strategies for Pharmaceutical Professionals
When looking to buy (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone, pharmaceutical companies prioritize suppliers who can guarantee:
* High Purity: Typically, a purity of >99% is required, with strict controls on specific impurities, water content, and heavy metals.
* Reliable Supply Chain: A consistent and stable supply is crucial to avoid disruptions in API manufacturing. Partnering with a reputable manufacturer in China, known for its robust chemical production capabilities, is often a strategic choice.
* Competitive Pricing: Securing this intermediate at a good price without compromising quality is essential for managing production costs effectively.
* Regulatory Compliance: The intermediate should be produced under conditions that align with pharmaceutical industry expectations regarding quality and traceability.
As NINGBO INNO PHARMCHEM CO.,LTD., we pride ourselves on being a premier supplier of (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone. We understand the critical needs of our B2B clients – the R&D scientists developing new formulations and the procurement managers ensuring seamless production. Our state-of-the-art manufacturing facilities and rigorous quality control processes ensure that you receive an intermediate that adheres to the highest industry standards.
For those involved in the synthesis of Dapagliflozin, sourcing your (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone from a trusted partner like us means investing in the success of your pharmaceutical products. We encourage you to reach out for a quotation and sample to experience the quality and reliability we offer.
Perspectives & Insights
Nano Explorer 01
“Its specific chemical structure, featuring bromine and chlorine substituents on one phenyl ring and an ethoxy group on the other, is precisely what is required to efficiently build the complex molecular architecture of Dapagliflozin.”
Data Catalyst One
“The purity of this intermediate is directly correlated to the purity of the final API.”
Chem Thinker Labs
“Impurities present in the intermediate can carry through the synthesis process, leading to lower yields, the need for costly purification steps, or even the failure to meet regulatory standards.”