Diethyl Chloromalonate (CAS 14064-10-9) is a chemical compound of significant interest across various scientific and industrial sectors, particularly in organic synthesis. As a clear, colorless liquid, it possesses a unique set of properties that make it a valuable intermediate for researchers and manufacturers alike. This guide aims to provide a detailed overview of Diethyl Chloromalonate, covering its characteristics, applications, and essential considerations for sourcing.

Key Properties of Diethyl Chloromalonate:

At a molecular level, Diethyl Chloromalonate has the formula C7H11ClO4 and a molecular weight of 194.61. It is characterized by its liquid state at room temperature, with a density of approximately 1.204 g/mL at 25°C. Its boiling point is around 221-222°C, and it has a flash point exceeding 230°F, indicating relative stability under normal handling conditions. The refractive index is typically reported as n20/D 1.432. For safety and storage, it is recommended to keep it in a cool, dry place, tightly closed, and potentially under an inert atmosphere for long-term preservation.

Applications in Chemical Synthesis:

The primary utility of Diethyl Chloromalonate lies in its role as a versatile building block in organic synthesis. It is frequently employed in:

  • Pharmaceutical Intermediates: As a precursor for synthesizing various active pharmaceutical ingredients (APIs) and complex drug molecules.
  • Agrochemicals: Contributing to the development of pesticides, herbicides, and other crop protection agents.
  • Domino Reactions: Participating in K2CO3-catalyzed domino reactions for the synthesis of heterocyclic compounds like 2,3-dihydrobenzofurans.
  • QSAR Modeling: Used in Quantitative Structure-Activity Relationship (QSAR) modeling for chemical toxicants, particularly in aquatic toxicity studies.

Sourcing Diethyl Chloromalonate: A Manufacturer's Perspective

For businesses looking to buy Diethyl Chloromalonate, sourcing from reputable manufacturers is key to ensuring product quality and supply chain reliability. As a leading manufacturer and supplier in China, we offer Diethyl Chloromalonate with a guaranteed purity of ≥97.0%. Our commitment is to provide cost-effective solutions without compromising on quality, making us an ideal partner for both research and industrial-scale applications.

When evaluating suppliers, consider factors such as product purity, batch-to-batch consistency, delivery times, and customer support. We are dedicated to meeting these requirements and are happy to provide detailed specifications and quotes for your needs. Partner with a trusted source for your Diethyl Chloromalonate requirements and ensure the success of your synthetic endeavors.