Di(1H-pyrrol-2-yl)methane, a compound identified by CAS 21211-65-4, is a fundamental intermediate in various chemical synthesis pathways, most notably for porphyrin synthesis. As a dedicated manufacturer and supplier based in China, we provide critical insights into this compound's synthesis, properties, and the importance of reliable sourcing for your operations.

The synthesis of Di(1H-pyrrol-2-yl)methane typically involves the acid-catalyzed condensation of pyrrole with formaldehyde. Various synthetic routes exist, with methods employing catalysts like indium(III) chloride (InCl₃) or trifluoroacetic acid (TFA) often cited for their efficiency. The optimization of reaction conditions, including catalyst choice, temperature, and reaction time, is crucial to maximize yield and minimize the formation of byproducts such as tripyrranes or oligomers. While often appearing as a gray solid, its precise physical form can vary, and it requires careful handling due to its susceptibility to oxidation.

Key properties include its molecular formula C9H10N2 and a molecular weight of approximately 146.19 g/mol. Its melting point typically falls between 72.0 to 77.0 °C. Spectroscopic analysis, particularly NMR and Mass Spectrometry, is vital for confirming its structure and purity. For applications in porphyrin synthesis, high purity is paramount to ensure successful cyclization and to obtain desired porphyrin structures.

The versatility of Di(1H-pyrrol-2-yl)methane extends beyond porphyrins into medicinal chemistry and materials science. Derivatives are explored for antimicrobial, anticancer, and anti-inflammatory activities, and its structure is utilized in creating advanced materials like chemosensors and conductive polymers. Understanding these diverse applications underscores the demand for a consistent and reliable supply chain.

As a leading supplier in China, we are committed to delivering high-quality Di(1H-pyrrol-2-yl)methane. We understand the critical need for purity and timely delivery in research and industrial settings. If you are looking to buy this essential chemical intermediate, considering its price and availability from a trusted source like us is paramount. Partnering with us ensures you receive a product that meets rigorous standards, supporting your synthetic goals and product development.