Understanding DL-2-Bromopropionic Acid (CAS 598-72-1): Properties and Uses
DL-2-Bromopropionic acid, often referred to by its CAS number 598-72-1, is a chemical compound that plays a significant role as an intermediate in various industrial processes. Understanding its physical and chemical properties is crucial for its effective handling and application. This compound is primarily recognized for its utility in organic synthesis, particularly in the pharmaceutical and agrochemical sectors. Ningbo Inno Pharmchem Co., Ltd., a prominent manufacturer in China, provides this essential chemical, ensuring high purity and reliability for its customers.
The chemical structure of DL-2-Bromopropionic acid is C3H5BrO2, with a molecular weight of approximately 152.97 g/mol. It is typically described as a clear, colorless to yellowish liquid after melting. Its melting point is around 25.7°C, meaning it can exist as a solid at cooler room temperatures. The compound exhibits good solubility in water and is miscible with common organic solvents such as alcohol, ether, chloroform, and benzene. This solubility profile is advantageous, allowing for its use in a wide range of reaction conditions. The density of DL-2-Bromopropionic acid is approximately 1.7 g/mL at 25°C, making it denser than water. Its boiling point is around 203°C, although it may decompose at higher temperatures. The pKa of its carboxylic acid group is approximately 2.97, indicating its acidic nature.
The reactivity of DL-2-Bromopropionic acid is a key factor in its widespread use. The presence of the bromine atom alpha to the carboxylic acid group makes the carbon atom susceptible to nucleophilic substitution reactions. This characteristic allows it to act as a versatile reagent in organic synthesis. It is commonly used as an alkylating agent, particularly for mercaptans and other sulfur-containing compounds. Furthermore, it finds application in polymer chemistry, including emulsion polymerization and the preparation of reversible addition-fragmentation chain transfer (RAFT) agents, which are vital for controlled polymerization techniques.
The applications of DL-2-Bromopropionic acid are diverse and impactful. In pharmaceutical synthesis, it serves as a critical building block for active pharmaceutical ingredients (APIs). It is instrumental in the preparation of certain amino acids and their derivatives, which are fundamental to many drug formulations. Its role extends to the synthesis of compounds used in anti-inflammatory, antiviral, and even anti-cancer drug development. The ability to introduce specific chemical motifs into complex molecules makes it invaluable for medicinal chemists. For those looking to buy DL-2-Bromopropionic acid, choosing a reputable supplier like Ningbo Inno Pharmchem Co., Ltd. ensures access to a high-quality intermediate.
In the agrochemical industry, DL-2-Bromopropionic acid is employed in the synthesis of key crop protection agents. It is used to produce herbicides such as quizalofop-ethyl, napropamide, and fenthiaprop, as well as fungicides like metalaxyl, benalaxyl, and procymidone. These compounds are essential for ensuring healthy crops and maximizing agricultural yields. The consistent demand for these agrochemicals underscores the importance of a stable supply chain for intermediates like DL-2-Bromopropionic acid.
Ningbo Inno Pharmchem Co., Ltd. is a leading manufacturer and supplier committed to providing high-purity DL-2-Bromopropionic acid. With a focus on stringent quality control and advanced manufacturing processes, we ensure that our chemical intermediates meet the exacting standards of the pharmaceutical and agrochemical industries. Our global reach and dedication to customer service make us a reliable partner for your chemical sourcing needs.
The chemical structure of DL-2-Bromopropionic acid is C3H5BrO2, with a molecular weight of approximately 152.97 g/mol. It is typically described as a clear, colorless to yellowish liquid after melting. Its melting point is around 25.7°C, meaning it can exist as a solid at cooler room temperatures. The compound exhibits good solubility in water and is miscible with common organic solvents such as alcohol, ether, chloroform, and benzene. This solubility profile is advantageous, allowing for its use in a wide range of reaction conditions. The density of DL-2-Bromopropionic acid is approximately 1.7 g/mL at 25°C, making it denser than water. Its boiling point is around 203°C, although it may decompose at higher temperatures. The pKa of its carboxylic acid group is approximately 2.97, indicating its acidic nature.
The reactivity of DL-2-Bromopropionic acid is a key factor in its widespread use. The presence of the bromine atom alpha to the carboxylic acid group makes the carbon atom susceptible to nucleophilic substitution reactions. This characteristic allows it to act as a versatile reagent in organic synthesis. It is commonly used as an alkylating agent, particularly for mercaptans and other sulfur-containing compounds. Furthermore, it finds application in polymer chemistry, including emulsion polymerization and the preparation of reversible addition-fragmentation chain transfer (RAFT) agents, which are vital for controlled polymerization techniques.
The applications of DL-2-Bromopropionic acid are diverse and impactful. In pharmaceutical synthesis, it serves as a critical building block for active pharmaceutical ingredients (APIs). It is instrumental in the preparation of certain amino acids and their derivatives, which are fundamental to many drug formulations. Its role extends to the synthesis of compounds used in anti-inflammatory, antiviral, and even anti-cancer drug development. The ability to introduce specific chemical motifs into complex molecules makes it invaluable for medicinal chemists. For those looking to buy DL-2-Bromopropionic acid, choosing a reputable supplier like Ningbo Inno Pharmchem Co., Ltd. ensures access to a high-quality intermediate.
In the agrochemical industry, DL-2-Bromopropionic acid is employed in the synthesis of key crop protection agents. It is used to produce herbicides such as quizalofop-ethyl, napropamide, and fenthiaprop, as well as fungicides like metalaxyl, benalaxyl, and procymidone. These compounds are essential for ensuring healthy crops and maximizing agricultural yields. The consistent demand for these agrochemicals underscores the importance of a stable supply chain for intermediates like DL-2-Bromopropionic acid.
Ningbo Inno Pharmchem Co., Ltd. is a leading manufacturer and supplier committed to providing high-purity DL-2-Bromopropionic acid. With a focus on stringent quality control and advanced manufacturing processes, we ensure that our chemical intermediates meet the exacting standards of the pharmaceutical and agrochemical industries. Our global reach and dedication to customer service make us a reliable partner for your chemical sourcing needs.
Perspectives & Insights
Quantum Pioneer 24
“In pharmaceutical synthesis, it serves as a critical building block for active pharmaceutical ingredients (APIs).”
Bio Explorer X
“It is instrumental in the preparation of certain amino acids and their derivatives, which are fundamental to many drug formulations.”
Nano Catalyst AI
“Its role extends to the synthesis of compounds used in anti-inflammatory, antiviral, and even anti-cancer drug development.”