For professionals in the chemical and pharmaceutical industries, a thorough understanding of key intermediates is vital. 6-Maleimidohexanoic Acid N-Hydroxysuccinimide Ester, known as EMCS and bearing CAS number 55750-63-5, is one such critical compound. This article provides essential information on its properties, applications, and procurement best practices for businesses looking to buy this versatile chemical.

EMCS is a heterobifunctional crosslinker, meaning it possesses two distinct reactive groups that can be used to link different molecules. Its maleimide group is highly reactive towards sulfhydryl (thiol) groups, forming stable thioether bonds. The N-hydroxysuccinimide (NHS) ester group, on the other hand, readily reacts with primary amines to form amide bonds. This dual reactivity makes EMCS exceptionally useful for a wide array of applications, including enzyme labeling, protein conjugation, and the synthesis of antibody-drug conjugates (ADCs).

The typical specifications for EMCS include a high purity level, often 99%, and an appearance of white to cream colored crystals. These characteristics are important for ensuring the efficacy and predictability of conjugation reactions. For instance, in the preparation of enzyme immunoconjugates or hapten carrier molecule conjugates, the purity of the EMCS used directly impacts the success rate and the quality of the final product.

When considering procurement, businesses should look for reputable manufacturers and suppliers, particularly those based in China, known for their robust fine chemical production capabilities. It is advisable to request a detailed quote that includes product specifications, packaging options (e.g., 25kg/drum), and delivery terms. Building a relationship with a supplier who can provide consistent quality and timely delivery is crucial for maintaining operational efficiency. For anyone needing to buy EMCS, understanding its properties and sourcing it strategically will support innovation in their respective fields.