In the intricate world of pharmaceutical synthesis, certain chemical compounds stand out for their indispensable roles. Endo-3-Amine-9-Methyl-9-Azabicyclo[3.3.1]Nonane, identified by its CAS number 76272-56-5, is one such molecule. Primarily recognized as a key intermediate in the synthesis of Granisetron Hydrochloride, a widely prescribed medication for nausea and vomiting, this bicyclic amine plays a critical role in modern medicine. For R&D scientists and procurement managers looking to buy this compound, a deep understanding of its properties is essential.

Chemical Identity and Structure

Endo-3-Amine-9-Methyl-9-Azabicyclo[3.3.1]Nonane possesses a unique molecular structure that lends itself to specific synthetic pathways. Its molecular formula is C9H18N2, with a molecular weight of approximately 154.25 g/mol. The bicyclic framework, featuring an azabicyclo[3.3.1]nonane core with an amine group in the 3-endo position and a methyl group on the nitrogen at position 9, is crucial for its reactivity and suitability as a precursor. The precise stereochemistry is vital for its efficacy in downstream reactions.

Key Properties and Specifications

As a product offered by manufacturers, Endo-3-Amine-9-Methyl-9-Azabicyclo[3.3.1]Nonane typically exhibits specific physical and chemical properties. It is often described as a colorless or yellowish transparent liquid with a density of around 0.968 g/cm³. Its boiling point is noted at 115-119°C at 18 mmHg. Critically for pharmaceutical applications, high purity is paramount. Reputable suppliers guarantee a purity of ≥98.5%, with strict limits on water (≤1.0%), oxime (≤0.2%), and individual/total impurities (≤0.5% / ≤1.5%). These specifications are critical for ensuring the quality of the final API.

Applications Beyond Granisetron Synthesis

While its role as a Granisetron Hydrochloride intermediate is its most prominent application, the unique structural features of Endo-3-Amine-9-Methyl-9-Azabicyclo[3.3.1]Nonane make it a valuable compound in other areas of organic synthesis and medicinal chemistry. It can serve as a chiral building block for the development of novel therapeutic agents or as a reference standard for impurity analysis in pharmaceutical manufacturing. Researchers in academic institutions and R&D departments of pharmaceutical companies often seek this compound for their exploratory projects. Enquiring about its availability from a reliable manufacturer for R&D purposes is a common step.

Procurement and Supplier Considerations

For procurement managers, identifying a dependable supplier or manufacturer of CAS 76272-56-5 is a strategic priority. Factors such as consistent quality, competitive pricing, reliable lead times, and robust technical support are crucial. Establishing a relationship with a manufacturer that can assure batch-to-batch consistency and provide necessary documentation is key to a smooth production workflow. When considering how to purchase this intermediate, always request detailed specifications and analytical data to confirm it meets your exact requirements.

Conclusion

Endo-3-Amine-9-Methyl-9-Azabicyclo[3.3.1]Nonane is more than just a chemical; it is an enabler of critical pharmaceutical treatments. Its precise chemical structure, combined with high purity standards, makes it an indispensable component in the synthesis of Granisetron Hydrochloride. Understanding its characteristics and sourcing it from reputable manufacturers ensures the integrity and success of pharmaceutical production.