The chemical industry thrives on the efficient utilization of specialized intermediates that facilitate complex synthesis processes. Ethyl 2-chloronicotinate, bearing the CAS number 1452-94-4, is a prime example of such a compound, playing a significant role in the production of pharmaceuticals and other fine chemicals. Understanding its properties and chemical behavior is crucial for chemists and procurement specialists involved in its sourcing and application.

Chemically, Ethyl 2-chloronicotinate is a derivative of nicotinic acid, featuring a pyridine ring substituted with a chlorine atom at the 2-position and an ethyl ester group at the 3-position. Its molecular formula is C8H8ClNO2, with a molecular weight of approximately 185.61 g/mol. Typically supplied as a liquid, it exhibits a color ranging from colorless to light yellow or light orange. The reported density is around 1.2445 g/cm³ at 25°C, and its boiling point is approximately 78°C at 0.1 mmHg, indicating its stability under controlled conditions. For storage, it's recommended to keep it in a dark, dry, and well-sealed container, away from oxidizing agents to maintain its integrity.

The chemical significance of Ethyl 2-chloronicotinate lies in its reactive sites. The chlorine atom is susceptible to nucleophilic displacement reactions, allowing for the introduction of various functional groups onto the pyridine core. This makes it an excellent precursor for creating a diverse array of substituted pyridine compounds, which are prevalent in many biologically active molecules. The ethyl ester group can also undergo transformations such as hydrolysis to the carboxylic acid, or reduction to an alcohol, further expanding its synthetic utility.

For R&D scientists and procurement managers, identifying reliable sources is paramount. When you buy Ethyl 2-chloronicotinate, it's important to select a supplier or manufacturer that can guarantee product quality and provide comprehensive technical data. Information regarding its chemical properties, purity levels (often specified as ≥98%), and safe handling procedures is vital for effective laboratory use and industrial application.

The price of this intermediate is influenced by factors such as purity, order volume, and market demand. Sourcing from established Chinese chemical manufacturers can offer competitive pricing, especially for larger quantities needed for production runs. Engaging with a reputable company ensures that you receive a product that meets stringent quality standards, crucial for the sensitive applications in pharmaceutical and fine chemical synthesis.

In conclusion, Ethyl 2-chloronicotinate is a highly functionalized chemical intermediate that offers significant versatility in organic synthesis. Its well-defined chemical properties and reactivity make it an invaluable component for chemists. By partnering with dependable chemical manufacturers and suppliers, researchers and industries can effectively leverage this compound for their innovative projects, ensuring both quality and cost-effectiveness.