Fmoc-D-Isoleucine, identified by its CAS number 143688-83-9, is a critical chiral building block widely utilized in the field of peptide synthesis and medicinal chemistry. As an N-protected derivative of the D-enantiomer of isoleucine, it plays a pivotal role in constructing peptides with specific structural and functional characteristics. For B2B clients, understanding its properties and applications is key to optimizing their research and development processes.

Chemically, Fmoc-D-Isoleucine possesses a molecular weight of 353.41 g/mol and the molecular formula C21H23NO4. It typically presents as a white to off-white powder, a physical form that facilitates accurate weighing and handling in laboratory settings. Its solubility in common organic solvents like chloroform, dichloromethane, and DMSO makes it compatible with various peptide synthesis protocols, particularly solid-phase peptide synthesis (SPPS). The Fmoc protecting group is labile to base, allowing for its selective removal under mild conditions, which is crucial for maintaining the integrity of the peptide backbone during synthesis.

The primary application of Fmoc-D-Isoleucine lies in its use as a monomer in the synthesis of peptides. Incorporating D-amino acids into a peptide sequence can confer several advantages, including increased resistance to proteolysis, which enhances the peptide's stability and longevity in biological systems. This makes Fmoc-D-Ile-OH an invaluable component for peptide-based drug development, where improved pharmacokinetic profiles are often desired. Furthermore, the stereochemistry of D-amino acids can influence peptide conformation and binding affinity to target receptors.

When considering the purchase of Fmoc-D-Isoleucine, it is essential to source from reputable manufacturers and suppliers who can guarantee high purity and consistency. Purity levels, often exceeding 98.5% by chiral HPLC, are critical for the success of peptide synthesis. Buyers should look for suppliers who provide comprehensive technical documentation, including CoAs and SDSs. Pricing can vary significantly, so obtaining quotes from several trusted providers is advisable, especially for bulk quantities.

In conclusion, Fmoc-D-Isoleucine is a fundamental reagent for anyone involved in advanced peptide synthesis and drug discovery. Its unique properties as a protected D-amino acid make it an indispensable tool. If you are looking to buy Fmoc-D-Ile-OH, prioritize suppliers who offer guaranteed purity, reliable supply, and competitive pricing. Investing in quality reagents ensures the efficiency and success of your peptide synthesis projects and accelerates your journey in pharmaceutical development.