For professionals in peptide chemistry, a thorough understanding of the building blocks used is crucial for successful synthesis. Fmoc-D-Lys(Mtt)-OH is one such essential reagent, widely employed in Fmoc solid-phase peptide synthesis (SPPS). This article provides a detailed look at its properties, benefits, and why sourcing it from a reputable manufacturer and supplier is vital.

Fmoc-D-Lys(Mtt)-OH, chemically known as N-alpha-(9-fluorenylmethoxycarbonyl)-N-epsilon-(4-methyltrityl)-D-lysine, combines the Fmoc protecting group on the alpha-amino terminus with the Mtt protecting group on the epsilon-amino group of D-lysine. The Fmoc group offers base-lability, compatible with the standard Fmoc SPPS deprotection cycles, typically using piperidine. The Mtt group, on the other hand, is acid-labile and orthogonally removable. This orthogonality is a key advantage, allowing for selective deprotection of the lysine side chain under specific acidic conditions without affecting other acid-labile protecting groups commonly used in SPPS. This selective functionalization capability makes it an attractive option for those looking to buy specialized amino acid derivatives.

The advantages of using Fmoc-D-Lys(Mtt)-OH are significant for custom peptide synthesis. It allows for the introduction of lysine residues with a protected side chain that can be selectively deprotected later in the synthesis or after resin cleavage for further modification. This is invaluable for creating peptides with branching, labeling, or conjugation points. As a dedicated manufacturer and supplier, we ensure that our Fmoc-D-Lys(Mtt)-OH meets high purity standards, which is critical for preventing side reactions and ensuring the integrity of the final peptide sequence. Researchers in academia and industry rely on such high-quality building blocks to achieve reproducible results.

For procurement managers and lab heads, identifying a reliable source for these specialized chemicals is paramount. We offer Fmoc-D-Lys(Mtt)-OH from our manufacturing facility, ensuring quality control and competitive pricing. Whether you need small quantities for initial research or bulk orders for scale-up, our team is equipped to meet your demands. We invite you to request a quote and discover the advantages of partnering with a committed supplier for all your peptide synthesis reagent needs.