In the dynamic world of peptide chemistry, precise molecular construction is key. At the heart of modern peptide synthesis lies a repertoire of protected amino acids, and among these, Fmoc-Gln-OH (CAS: 118609-68-0) stands out as a particularly important building block. Understanding its properties and applications is fundamental for anyone involved in peptide research and production.

Fmoc-Gln-OH, also known by its chemical name N-alpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-Glutamine, is characterized by its Fmoc protecting group attached to the alpha-amino nitrogen of L-glutamine. The Fmoc group is a cornerstone of the Fmoc/tBu strategy, a widely adopted method for solid-phase peptide synthesis. Its key advantage lies in its lability under mild basic conditions, allowing for stepwise deprotection without damaging acid-sensitive side-chain protecting groups or the growing peptide chain. This orthogonality is crucial for building complex peptide sequences with high fidelity.

The L-glutamine residue itself, with its amide-containing side chain (-CH2-CH2-CONH2), is prevalent in natural proteins. Its inclusion in synthetic peptides can influence factors like solubility, protein-protein interactions, and specific binding affinities. Therefore, the availability of high-quality Fmoc-Gln-OH is essential for researchers aiming to replicate or engineer peptide structures with biological relevance.

The standard specifications for Fmoc-Gln-OH (CAS 118609-68-0) typically include its molecular formula (C20H20N2O5) and molecular weight (approximately 368.38 g/mol). These identifiers are critical for accurate stoichiometric calculations during synthesis. Purity is paramount; research-grade and pharmaceutical-grade Fmoc-Gln-OH should exhibit very high purity levels, usually above 98% or 99%, to minimize side reactions and ensure the integrity of the final peptide product. When procuring this reagent, always consult the supplier's Certificate of Analysis (CoA).

The applications of Fmoc-Gln-OH span various fields:

  • Solid-Phase Peptide Synthesis (SPPS): This is its primary application, enabling the stepwise addition of glutamine residues into a growing peptide chain.
  • Drug Discovery: As a component of peptide-based therapeutics, research into new drugs often involves synthesizing peptides containing glutamine.
  • Biochemical Research: Used to synthesize peptides for studying enzyme mechanisms, receptor binding, and other biological processes.
  • Peptidomimetics: Can be incorporated into modified peptide structures to enhance stability or alter biological activity.

For those looking to buy Fmoc-Gln-OH, understanding the market for chemical reagents is beneficial. Many reliable manufacturers and suppliers, including those in China, offer this product. Comparing the Fmoc-Gln-OH price from different sources is advisable, but always prioritize product quality and consistent supply from reputable vendors. Whether you are a seasoned peptide chemist or embarking on new research, ensuring you have access to high-grade Fmoc-Gln-OH is a fundamental step towards successful peptide synthesis.