For professionals in the chemical and pharmaceutical industries, understanding the properties and applications of key intermediates is vital for making informed purchasing decisions. Nalpha-Fmoc-Ndelta-trityl-L-glutamine, commonly referred to as Fmoc-Gln(Trt)-OH, with CAS number 132327-80-1, is a highly sought-after amino acid derivative used extensively in peptide synthesis. This article aims to provide a comprehensive overview for those looking to buy this compound.

Fmoc-Gln(Trt)-OH is characterized by its high purity, typically exceeding 99%, and its molecular formula C39H34N2O5, with a molecular weight of 610.70 g/mol. The compound appears as a white to off-white powder. Its primary utility lies in its ability to protect both the alpha-amino group (via Fmoc) and the gamma-amide side chain (via the trityl group) of glutamine. This dual protection is crucial for preventing unwanted side reactions during peptide synthesis.

The key advantages for buyers considering Fmoc-Gln(Trt)-OH include its superior solubility in polar organic solvents like DMF, which aids in homogeneous reaction conditions. More importantly, the trityl group effectively prevents the dehydration of the glutamine side chain, a common issue that can lead to the formation of pyroglutamic acid or succinimide derivatives. This protection ensures that the glutamine residue is incorporated accurately into the peptide sequence, resulting in cleaner products and higher overall yields. This makes it a cost-effective choice for manufacturers when they purchase in bulk.

When seeking to purchase Fmoc-Gln(Trt)-OH, it is advisable to partner with established manufacturers and suppliers. Reputable suppliers, often based in regions like China, offer competitive pricing and adhere to stringent quality control measures, ensuring lot-to-lot consistency. These suppliers can provide detailed Certificates of Analysis (CoA) and material safety data sheets (MSDS), which are essential for regulatory compliance and safe handling. Whether for research or large-scale production, understanding these properties will guide you to the best source for your Nalpha-Fmoc-Ndelta-trityl-L-glutamine needs.