In the realm of chemical research, certain compounds stand out due to their versatility and importance in enabling complex scientific endeavors. Fmoc-Glu-OFm, identified by CAS number 200616-18-8, is one such molecule. As an Fmoc-protected amino acid derivative, it plays a critical role in various research applications, most notably in peptide synthesis and broader organic chemistry. Understanding its chemical properties and application scope is fundamental for any researcher working in these fields.

Fmoc-Glu-OFm is derived from the amino acid L-glutamic acid. Its chemical structure features the defining Fmoc (9-fluorenylmethyloxycarbonyl) protecting group attached to the alpha-amino group and a fluorenylmethyl ester protecting the side-chain carboxyl group. This dual protection strategy is key to its utility. The Fmoc group is known for its facile removal under mild basic conditions (e.g., using piperidine), a process compatible with the acid-labile nature of resins and side-chain protecting groups commonly employed in Solid Phase Peptide Synthesis (SPPS). The fluorenylmethyl ester on the side chain offers orthogonal protection, meaning it can be removed independently of the Fmoc group or other protecting groups, allowing for greater flexibility in complex synthetic pathways.

The primary research application of Fmoc-Glu-OFm is as a building block in the synthesis of peptides. Researchers utilize it to introduce glutamic acid residues into specific positions within a peptide sequence. This is crucial for studies involving protein structure-function relationships, the design of novel peptide-based therapeutics, and the development of diagnostic tools. The high purity of Fmoc-Glu-OFm, typically exceeding 98%, is essential for these applications, as impurities can lead to the formation of undesired peptide sequences, compromising experimental results. When researchers seek to buy Fmoc-Glu-OFm for their experiments, they prioritize suppliers who can consistently deliver this high purity.

Beyond peptide synthesis, Fmoc-Glu-OFm finds application in broader organic synthesis projects where the protected glutamic acid moiety is required. This might involve the synthesis of complex natural products, small molecule drug candidates, or specialized chemical probes. Its well-defined chemical properties, including its molecular formula (C34H29NO6) and molecular weight (547.60), allow for precise stoichiometric calculations in reactions. Reliable manufacturers and suppliers, particularly those in China with competitive pricing, are valuable partners for research institutions and chemical companies that require a steady supply of this versatile reagent.

In summary, Fmoc-Glu-OFm is an indispensable reagent for researchers engaged in peptide chemistry and organic synthesis. Its carefully designed protective groups and high purity enable sophisticated molecular constructions. By sourcing this compound from reputable manufacturers, scientists can ensure the integrity of their research and drive innovation in various scientific disciplines.