Understanding Fmoc-Gly-Gly-Gly-Gly-OH: Properties and Synthesis Applications
Fmoc-Gly-Gly-Gly-Gly-OH, or N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycylglycylglycylglycine, is characterized by its specific chemical structure. It features a glycine tetramer where the N-terminus is protected by the Fmoc group. This protective moiety is vital for selective deprotection during solid-phase peptide synthesis (SPPS) or solution-phase synthesis, allowing for controlled addition of amino acids. The compound typically presents as a white solid, with a defined molecular weight of 468.46 and a density of 1.367. Its predicted boiling point is around 930.4±65.0 °C, and it requires storage at 2-8°C to maintain stability. For chemists, sourcing this material from reliable manufacturers ensures consistent purity, which is paramount for successful synthesis and achieving target yields. The procurement of these compounds often involves comparing prices from various suppliers.
The primary application of Fmoc-Gly-Gly-Gly-Gly-OH lies in peptide synthesis. It serves as a versatile building block, enabling chemists to construct peptides with specific sequences and lengths efficiently. This is particularly important in the pharmaceutical industry for developing peptide-based drugs and in biotechnology for creating functional peptides used in research and diagnostics. The Fmoc chemistry employed allows for stepwise synthesis, where each amino acid or peptide fragment is added sequentially, with the Fmoc group being removed just before the next coupling step. This controlled approach minimizes side reactions and maximizes the yield of the desired product.
Beyond standard peptide synthesis, Fmoc-Gly-Gly-Gly-Gly-OH can also be incorporated into more complex molecular architectures. Its integration into peptidomimetics or as part of larger biomolecules expands its utility. The chemical industry relies on such specialized reagents to innovate and develop new materials and therapeutics. Companies like NINGBO INNO PHARMCHEM CO.,LTD. play a crucial role by ensuring the availability of these critical synthesis components. Their understanding of the market demand and commitment to quality make them a valuable partner for chemists worldwide.
In essence, Fmoc-Gly-Gly-Gly-Gly-OH is more than just a chemical compound; it's a key enabler of scientific progress in peptide chemistry. Its well-defined properties and broad synthesis applications make it a must-have reagent for many research and industrial laboratories. By sourcing this critical component from trusted suppliers such as NINGBO INNO PHARMCHEM CO.,LTD., chemists can confidently pursue their synthetic goals, contributing to advancements in medicine and biotechnology.
Perspectives & Insights
Molecule Vision 7
“It serves as a versatile building block, enabling chemists to construct peptides with specific sequences and lengths efficiently.”
Alpha Origin 24
“This is particularly important in the pharmaceutical industry for developing peptide-based drugs and in biotechnology for creating functional peptides used in research and diagnostics.”
Future Analyst X
“The Fmoc chemistry employed allows for stepwise synthesis, where each amino acid or peptide fragment is added sequentially, with the Fmoc group being removed just before the next coupling step.”