For professionals in organic synthesis and chemical manufacturing, understanding the precise properties and applications of key intermediates is vital. Fmoc-L-Methionine (CAS 71989-28-1) stands out as a highly valuable reagent, particularly in the realm of peptide synthesis. NINGBO INNO PHARMCHEM CO.,LTD., as a dedicated manufacturer and supplier, offers insights into why this compound is indispensable in modern chemical synthesis.

Fmoc-L-Methionine is a derivative of the essential amino acid methionine, protected with the Fmoc group. Its chemical formula is C20H21NO4S, with a molecular weight of approximately 371.45. The Fmoc group is a cornerstone of the widely adopted Fmoc solid-phase peptide synthesis (SPPS) strategy. This strategy relies on the selective removal of the Fmoc protecting group using mild basic conditions (e.g., piperidine) without damaging the peptide chain or the resin support. This orthogonality allows for precise, sequential addition of amino acids, making it possible to synthesize complex peptide sequences with high fidelity.

The methionine residue itself offers unique properties. It contains a sulfur atom in its side chain, which can influence peptide conformation and is susceptible to oxidation. While oxidation can be a challenge, it also opens avenues for specific modifications or can be managed through careful handling and the use of scavengers during synthesis and cleavage. For chemists looking to buy Fmoc-L-Methionine, ensuring high purity is critical, as impurities can lead to undesired side reactions or incomplete coupling, ultimately compromising the yield and purity of the final peptide product. NINGBO INNO PHARMCHEM CO.,LTD. is committed to supplying Fmoc-L-Methionine that meets rigorous specifications, supporting the success of your synthetic endeavors.

The applications of Fmoc-L-Methionine extend across various branches of chemical synthesis. Primarily, it is a key building block for pharmaceutical intermediates and active pharmaceutical ingredients (APIs) that are peptide-based. Furthermore, it finds use in the synthesis of peptides for research purposes, including those used in proteomics, protein chemistry, and the development of novel materials. The ability to buy this reagent in bulk from a reliable manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. is crucial for scaling up production processes from laboratory research to industrial manufacturing.

In conclusion, Fmoc-L-Methionine (CAS 71989-28-1) is a vital component in the toolkit of any organic chemist involved in peptide synthesis. Its reliable performance in Fmoc SPPS, coupled with the inherent properties of the methionine residue, makes it invaluable for creating peptides with diverse functionalities. NINGBO INNO PHARMCHEM CO.,LTD. stands as a premier supplier in China, providing competitively priced, high-quality Fmoc-L-Methionine that empowers chemical professionals to achieve their synthesis goals.