In the specialized field of peptide chemistry, certain molecules serve as fundamental building blocks that unlock complex synthetic pathways. Fmoc-Ser(HPO3Bzl)-OH, identified by its CAS number 158171-14-3, is one such critical compound, indispensable for the synthesis of phosphopeptides. Understanding its structure, function, and how to effectively source it is vital for researchers and chemists in academic institutions and the pharmaceutical industry.

At its core, Fmoc-Ser(HPO3Bzl)-OH is a derivative of the amino acid L-serine. The 'Fmoc' prefix refers to the 9-fluorenylmethoxycarbonyl group, a widely used protecting group in Fmoc Solid-Phase Peptide Synthesis (SPPS). This group selectively masks the alpha-amino group of serine, allowing for controlled addition to a growing peptide chain. The 'Ser(HPO3Bzl)' part denotes the modification at the serine side chain. Here, the hydroxyl group of serine is phosphorylated, and this phosphate moiety is further protected by a benzyl ester. This specific protection scheme is crucial for the compound's utility.

The primary function of Fmoc-Ser(HPO3Bzl)-OH is to introduce a phosphorylated serine residue into a peptide sequence during SPPS. Phosphorylation is a ubiquitous post-translational modification that regulates a vast array of biological functions. By using this specialized building block, scientists can synthesize peptides that accurately mimic these phosphorylated forms. This is essential for studying kinase activity, protein-protein interactions mediated by phosphorylation, and for developing phosphopeptide-based therapeutics or diagnostic agents. For researchers looking to buy high-quality reagents for these applications, ensuring the correct protecting groups and purity is paramount.

The benzyl ester protection on the phosphate offers key advantages. It provides stability during the basic conditions used for Fmoc deprotection (typically with piperidine). This means the phosphate group remains intact throughout the elongation of the peptide chain. Subsequently, the benzyl group can be cleaved under specific conditions, such as catalytic hydrogenation, to reveal the free phosphate. This selective deprotection is a cornerstone of efficient and accurate phosphopeptide synthesis. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. ensure that their product meets stringent purity requirements, making it a reliable choice for your synthesis needs.

When considering procurement, buyers should look for suppliers that can guarantee the CAS number 158171-14-3 and specify a purity of 98% or higher. Engaging with a direct manufacturer often provides the best balance of quality, price, and supply chain reliability. These suppliers are experienced in producing complex organic molecules and can offer the technical support necessary for integrating such specialty reagents into your workflow. Whether you are engaged in fundamental research or developing new pharmaceutical products, securing a consistent supply of Fmoc-Ser(HPO3Bzl)-OH is a critical step.

In essence, Fmoc-Ser(HPO3Bzl)-OH is a sophisticated chemical tool that empowers researchers to explore the complex landscape of phosphorylated peptides. Its carefully designed structure and protective groups facilitate its use in advanced peptide synthesis, driving innovation in biochemical research and pharmaceutical development.