Folinic acid, identified by its CAS number 58-05-9, is a vital biochemical compound with significant applications in both pharmaceutical and nutritional industries. Commonly known as leucovorin, it is a derivative of folic acid that plays a critical role in various metabolic processes and therapeutic interventions. For procurement managers and R&D scientists, understanding its properties and reliable sourcing channels is key.

Chemically, folinic acid is N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid. It typically presents as an off-white to greenish-yellow powder, with a high purity level often exceeding 97.5%. This compound is distinguished by its metabolic activity, acting as a direct source of reduced folates for the body, thereby bypassing the enzymatic conversion step required by synthetic folic acid. This characteristic makes it particularly valuable in medical applications where folate metabolism might be compromised.

The primary pharmaceutical use of folinic acid is as an antidote or 'rescue' agent. It is extensively used to counteract the toxicity of methotrexate, an antifolate drug commonly employed in cancer chemotherapy and the treatment of certain autoimmune diseases. By providing the necessary reduced folate cofactors, folinic acid supports normal cellular functions, thereby protecting healthy tissues from the adverse effects of methotrexate overdose or high-dose therapy. Additionally, folinic acid is a crucial component in combination therapy for advanced colorectal cancer, where it enhances the efficacy of 5-fluorouracil by stabilizing its interaction with thymidylate synthase.

For researchers and product developers, sourcing high-quality folinic acid powder is essential. Manufacturers typically offer it in various packaging sizes, from grams for R&D to larger quantities for industrial production. When looking to buy folinic acid, prospective buyers should consider suppliers who can provide detailed specifications, such as melting point (around 245°C), density (estimated 1.4485 g/cm³), and solubility characteristics. These details are important for formulation and application development.

China has become a leading global supplier of pharmaceutical intermediates and fine chemicals, including folinic acid. Companies seeking reliable sources can find numerous manufacturers offering competitive pricing and consistent quality. When sourcing, it's advisable to partner with suppliers that provide comprehensive documentation and have robust quality assurance systems in place. This includes verifying purity levels and adherence to industry standards. For businesses aiming to procure folinic acid, reaching out to established chemical suppliers in China is often the most efficient way to ensure a stable and cost-effective supply chain.

In essence, folinic acid is a versatile and indispensable compound with critical roles in medical treatment and nutritional support. Its unique biochemical properties, combined with the availability of high-quality products from global manufacturers, make it a key ingredient for a wide range of applications. Pharmaceutical and nutraceutical companies should leverage the expertise of experienced suppliers to secure their supply of this vital chemical.