The central nervous system's intricate balance of excitatory and inhibitory signals is fundamental to its function. Gamma-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the mammalian brain, playing a crucial role in regulating neuronal excitability. Understanding the GABA receptor system is paramount for advancements in neuroscience, particularly in areas such as treating epilepsy, anxiety disorders, and sleep disturbances.

GABA receptor antagonists are chemical compounds that block or inhibit the action of GABA at its receptors, primarily the GABA-A receptor. By blocking GABA's inhibitory effect, these antagonists can increase neuronal excitability. This mechanism makes them invaluable tools for neuroscientists seeking to probe the complexities of synaptic transmission, neuronal excitability, and the overall functioning of neural circuits. Their application allows researchers to elucidate the physiological and pathological roles of the GABAergic system.

One such important compound is 3-Methylflavone-8-carboxylic acid (CAS 3468-01-7). This synthetic molecule is recognized for its antagonist properties towards the GABA receptor system. Its specific mode of action involves competitive inhibition at GABA-A receptor sites, thereby modulating the impact of GABA on neural activity. This makes it an indispensable tool for experimental pharmacology and studies focused on neurobiological mechanisms. Researchers use it to investigate how disruptions in GABAergic signaling contribute to various neurological conditions.

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