For professionals in the chemical and pharmaceutical industries, a deep understanding of key reagents is essential for successful synthesis and product development. O-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium Hexafluorophosphate, commonly known as HBTU (CAS 94790-37-1), is one such critical compound, primarily utilized as a coupling reagent in peptide synthesis. This article delves into the properties, specifications, and purchasing considerations for HBTU, offering guidance to researchers and procurement specialists.

HBTU is a highly effective reagent for promoting the formation of amide bonds, which are the essential linkages in peptides and proteins. Its chemical structure, characterized by the tetramethyluronium hexafluorophosphate moiety, allows it to activate carboxylic acids efficiently. This activation facilitates a rapid reaction with amine groups, leading to the formation of new amide bonds. A significant advantage of HBTU is its ability to minimize racemization, a critical factor in maintaining the chiral integrity of amino acids during peptide synthesis.

Typical specifications for HBTU from reputable manufacturers include a high purity level, often stated as ≥98% or ≥99% as determined by High-Performance Liquid Chromatography (HPLC). The physical appearance is usually described as a white to off-white crystalline powder. Key properties such as molecular formula (C11H16F6N5OP) and molecular weight (approximately 379.24 g/mol) are standard identifiers. Its melting point is typically around 200-212 °C (with decomposition), indicating good thermal stability for handling and storage.

When considering the purchase of HBTU, it is crucial to identify reliable suppliers who can guarantee product quality and consistency. For businesses in need of bulk quantities, sourcing from manufacturers in regions like China can offer cost advantages and robust supply chains. When inquiring about HBTU price or placing an order, providing precise details such as the required quantity, purity specifications, and intended application can help suppliers meet your needs effectively.

Storage and handling recommendations for HBTU generally include keeping it in a cool, dry place, protected from light and moisture, to maintain its efficacy and shelf life. As with all chemical reagents, adherence to safety data sheets (SDS) and laboratory safety protocols is paramount.

In summary, HBTU is a vital coupling reagent for anyone involved in peptide synthesis or other organic chemistry applications requiring efficient amide bond formation with minimal racemization. By understanding its properties and focusing on procurement from trusted suppliers, researchers and manufacturers can ensure the success of their synthetic projects.