In the realm of organic synthesis, certain reagents become indispensable tools for achieving complex transformations with efficiency and precision. 1-Hydroxybenzotriazole hydrate (HOBt hydrate) is one such reagent, widely celebrated for its pivotal role in peptide synthesis and its broader applications in amide bond formation. For chemists aiming to purchase reliable chemical intermediates, a thorough understanding of HOBt hydrate's properties and applications is essential.

HOBt hydrate, often recognized by its CAS number 123333-53-9, is a white crystalline solid. Its primary function in chemical synthesis is to act as an additive that enhances the efficiency of coupling reactions and crucially, suppresses racemization. This is particularly vital in peptide synthesis, where the coupling of amino acids to form peptide bonds can be prone to racemization, leading to a loss of the desired stereochemistry. By forming a more stable activated ester intermediate, HOBt hydrate allows for more controlled and efficient coupling, ensuring higher yields and stereochemical purity of the final peptide product.

Chemists utilize HOBt hydrate in conjunction with coupling agents such as carbodiimides. The mechanism involves the activation of a carboxylic acid to form an O-acylbenzotriazole. This activated species then reacts with an amine to form the amide bond. This method is far more effective than direct condensation and significantly reduces the likelihood of epimerization at the alpha-carbon of the amino acid. For researchers looking to buy high-quality reagents for peptide synthesis, including protected amino acids and coupling agents, HOBt hydrate is a standard inclusion in the reaction setup.

Beyond its primary use in peptide synthesis, HOBt hydrate is a valuable reagent for general amide synthesis from carboxylic acids, especially when direct conversion to acyl halides is problematic. This makes it a versatile tool for chemists working on a wide array of organic molecules, from pharmaceuticals to functional materials. When planning your next synthesis, consider sourcing HOBt hydrate from reputable manufacturers who can guarantee purity and consistency. Purchasing from a trusted supplier in China can offer competitive pricing and reliable supply chains.

The safety profile of HOBt hydrate is also an important consideration. While the hydrate form is generally considered safer than anhydrous HOBt, proper handling procedures and adherence to safety data sheet recommendations are always necessary. As a knowledgeable chemical supplier, we emphasize the importance of safe handling and provide comprehensive product information to our clients. We are committed to being a go-to source for chemists seeking reliable and high-performance chemical reagents for their groundbreaking research and development projects. Feel free to reach out for a quote or to discuss your specific needs.