In the realm of fine chemicals, Isobutylboronic acid (CAS: 84110-40-7) stands out as a crucial intermediate with a wide array of applications, particularly in organic synthesis and cross-coupling reactions. Understanding its fundamental properties, synthesis methods, and diverse uses is vital for researchers and procurement managers alike. As a professional manufacturer and supplier in China, we aim to provide clarity on this essential compound.

Isobutylboronic acid typically presents as a white powder, with a reported melting point generally between 108-111 °C. Its molecular formula is C4H11BO2, and its molecular weight is approximately 101.94 g/mol. The presence of the boronic acid functional group (-B(OH)2) makes it an excellent substrate for various transformations. Chemically, it acts as a Lewis acid and is particularly recognized for its role in the Suzuki-Miyaura coupling reaction, where it facilitates the formation of carbon-carbon bonds by reacting with organic halides or pseudohalides in the presence of a palladium catalyst and a base.

The synthesis of boronic acids, including Isobutylboronic acid, commonly involves the reaction of organometallic reagents, such as Grignard reagents or organolithium compounds, with borate esters, followed by hydrolysis. For instance, reacting isobutylmagnesium bromide with trimethyl borate and subsequent acidic workup yields Isobutylboronic acid. Alternative methods, such as palladium-catalyzed borylation of aryl halides, are also employed for preparing related boronic acid derivatives.

The applications of Isobutylboronic acid are extensive. It is a key building block in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. Its ability to participate in selective coupling reactions makes it indispensable for creating complex molecular structures required for drug discovery, the development of new pesticides, and the creation of novel polymers and electronic materials. For chemists seeking to buy Isobutylboronic acid, ensuring high purity (typically 97% min) from a reliable supplier is paramount for achieving successful and reproducible synthetic outcomes.

We are committed to providing high-quality Isobutylboronic acid to meet the diverse needs of the scientific and industrial communities. By understanding its properties and applications, you can better leverage this versatile intermediate in your research and production. Request a quote from us to explore competitive pricing and reliable supply options from our manufacturing facilities in China.