Lysophosphatidic acid (LPA) is a fascinating bioactive phospholipid that plays a pivotal role in a multitude of cellular processes. As a key signaling molecule, LPA influences everything from cell proliferation and survival to migration and differentiation. For researchers in lipidomics, cell biology, and pharmaceutical development, understanding the properties and applications of LPA is crucial.

What is Lysophosphatidic Acid?

LPA is a lipid mediator produced within the body and is also available as a high-purity chemical for research purposes. Typically, it consists of a glycerol backbone with a fatty acid attached at the sn-1 position and a phosphate group at the sn-3 position. The specific fatty acid chain, such as oleic acid in 1-Oleoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt), significantly influences its biological activity. This particular form is widely recognized for its potent effects on various cell types, including fibroblasts and vascular smooth muscle cells.

Key Biological Roles of LPA:

  • Cell Growth and Proliferation: LPA acts as a potent stimulator for the growth of a diverse range of cells, promoting their division and expansion.
  • Cellular Differentiation: It plays a role in guiding cells to differentiate into specific types, impacting tissue development and repair.
  • Signaling Pathways: LPA exerts its effects by binding to a family of G-protein coupled receptors (GPCRs), namely LPA1, LPA2, and LPA3, initiating intracellular signaling cascades.
  • Anti-Apoptotic Effects: LPA can promote cell survival by inhibiting programmed cell death (apoptosis), contributing to tissue homeostasis.

Applications in Research and Industry:

The multifaceted biological activities of LPA make it an invaluable tool in scientific research and potential therapeutic development. It is extensively used in:

  • Lipidomics studies: Analyzing the complex lipid profiles within cells and biological samples to understand metabolic pathways and disease states. Researchers often seek high-purity LPA for accurate quantitative analysis.
  • Drug discovery and development: Investigating LPA receptor pathways for potential therapeutic targets in areas such as cancer, fibrosis, and neurological disorders.
  • Drug delivery systems: The amphipathic nature of LPA can be utilized in the formulation of liposomes and nanoparticles for enhanced drug delivery.

Sourcing High-Quality LPA:

For procurement of essential research chemicals like 1-Oleoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt), it is vital to partner with a reliable manufacturer and supplier. NINGBO INNO PHARMCHEM CO.,LTD. is a premier supplier in China, offering high-purity LPA with a commitment to consistent quality and competitive pricing. We understand the critical nature of these compounds for your research. If you are looking to buy or purchase premium LPA for your laboratory or development projects, consider us your trusted source. We ensure that our product meets rigorous standards, making it suitable for all your demanding applications.

For inquiries on availability, pricing, or custom orders of Lysophosphatidic Acid, please contact our sales team. We are dedicated to supporting your scientific endeavors by providing the highest quality reagents.