Malate Dehydrogenase (MDH), classified under EC number 1.1.1.37, is a pivotal enzyme in cellular metabolism, primarily recognized for its role in the citric acid cycle (also known as the Krebs cycle) and gluconeogenesis. For researchers and manufacturers in the B2B chemical and pharmaceutical sectors, understanding the function and sourcing of high-quality MDH is paramount.

At its core, Malate Dehydrogenase catalyzes the reversible interconversion of L-malate to oxaloacetate, using NAD+ as a cofactor. This reaction is critical for regenerating NAD+ within the citric acid cycle, allowing the cycle to continue and efficiently produce ATP, the cell's primary energy currency. The enzyme also plays a crucial role in gluconeogenesis, the metabolic pathway that generates glucose from non-carbohydrate precursors. In this pathway, MDH helps shuttle oxaloacetate across the mitochondrial membrane, making it available for further conversion into glucose.

The significance of MDH extends to its use in various diagnostic applications. High-purity Malate Dehydrogenase is a key component in diagnostic kits used for determining the levels of enzymes like aspartate aminotransferase (AST/GOT), which are indicators of liver health. Therefore, ensuring a consistent and reliable supply of this enzyme is essential for diagnostic kit manufacturers. For businesses seeking to buy Malate Dehydrogenase, partnering with a reputable manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. ensures access to products meeting stringent quality standards.

When sourcing Malate Dehydrogenase, consider factors such as enzyme activity, purity, stability, and the supplier's commitment to quality control. A trusted supplier will offer detailed specifications and support for integrating the enzyme into your specific applications. Whether you are involved in biochemical assays, metabolic research, or the production of diagnostic reagents, securing a dependable source for Malate Dehydrogenase (CAS 9001-64-3) is a strategic move to ensure the efficacy and reliability of your products and research outcomes.