The field of cardiovascular research constantly seeks novel compounds to combat complex diseases like hypertension and thrombosis. NS-304 (CAS 475086-01-2), a key pharmaceutical intermediate, is at the forefront of research involving the prostacyclin signaling pathway. As a leading manufacturer in China specializing in high-quality chemical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. provides researchers and drug developers with access to this critical compound.

NS-304, also known as Selexipag, is meticulously designed to act as a prodrug. Upon administration, it is converted into its active metabolite, MRE-269. This active form is a potent and highly selective agonist for the prostacyclin IP receptor. The IP receptor is a G protein-coupled receptor found on platelets and vascular endothelial cells, mediating effects that include vasodilation and inhibition of platelet aggregation. By targeting this receptor, NS-304 offers a direct pathway to managing conditions associated with vascular dysfunction and increased vascular tone.

The pharmacological profile of NS-304 makes it an exceptional tool for various research applications. Its high affinity (Ki value of 20 nM for the human IP receptor) allows for precise studies on IP receptor activation and its downstream signaling effects. Researchers frequently utilize NS-304 in studies aimed at understanding the pathophysiology of pulmonary hypertension and exploring new therapeutic avenues. For those looking to buy NS-304 for these investigations, NINGBO INNO PHARMCHEM CO.,LTD. offers a dependable source. We are committed to delivering pharmaceutical-grade intermediates that facilitate accurate and reproducible scientific outcomes.

The long-acting nature of NS-304 is another significant advantage, providing sustained receptor activation and therapeutic effects. This characteristic is particularly important in developing chronic treatments for cardiovascular diseases. As a dedicated NS-304 supplier, we ensure consistent product quality and availability, supporting continuous research efforts. Partner with NINGBO INNO PHARMCHEM CO.,LTD. for your supply needs and experience the reliability of a top-tier pharmaceutical intermediate supplier.