Understanding Methyl 2-Cyanoisonicotinate: Properties and Pharmaceutical Applications
Methyl 2-cyanoisonicotinate, bearing the CAS number 94413-64-6, is a distinguished compound within the fine chemical industry, primarily recognized for its utility as a pharmaceutical intermediate. Its chemical name, Methyl 2-cyanoisonicotinate, alongside synonyms like 2-cyano-4-pyridine carboxylic acid methyl ester, highlights its pyridine derivative nature. This substance presents as a white crystalline powder, with a molecular formula of C8H6N2O2 and a molecular weight of 162.14500. The demand for this chemical stems largely from its indispensable role in the synthesis of Topiroxostat, a pharmaceutical agent developed for treating conditions like hyperuricemia and gout.
The physical and chemical properties of Methyl 2-cyanoisonicotinate are crucial for its effective application. It boasts a density of 1.25 g/cm³, a high boiling point of 296.6ºC at 760 mmHg, and a melting point typically between 107-109ºC. Its flash point is recorded at 133.2ºC, and it possesses a refractive index of 1.536, signifying stability under defined conditions. The compound's solubility in water is noted as slightly soluble (6.2 g/L at 25ºC), which is an important consideration for its handling and processing in various chemical reactions. Furthermore, stringent specifications such as loss on drying ≤2.0%, heavy metals ≤10 ppm, water content ≤1.0%, sulphated ash ≤0.5%, and total impurities ≤0.5% underscore its high quality standards. These detailed specifications are vital for any enterprise seeking a Methyl 2-cyanoisonicotinate manufacturer in China.
The primary application driving the demand for Methyl 2-cyanoisonicotinate is its function as a key intermediate in the production pathway of Topiroxostat. Topiroxostat, a xanthine oxidase inhibitor, is a vital medication for managing elevated uric acid levels, commonly associated with gout. The synthesis of Topiroxostat relies heavily on the purity and structural integrity of Methyl 2-cyanoisonicotinate. Beyond this crucial role, its versatile structure allows for its potential use in the synthesis of other biologically active molecules, including certain tetra-substituted imidazolines that act as neuropeptide Y (NPY) Y5 receptor antagonists. This versatility increases its value in drug discovery and development.
For companies in need of a reliable CAS 94413-64-6 supplier in China, understanding these properties and applications is essential. Partnering with a reputable Methyl 2-cyanoisonicotinate manufacturer ensures consistent quality and supply chain reliability, critical factors for successful pharmaceutical production.
The physical and chemical properties of Methyl 2-cyanoisonicotinate are crucial for its effective application. It boasts a density of 1.25 g/cm³, a high boiling point of 296.6ºC at 760 mmHg, and a melting point typically between 107-109ºC. Its flash point is recorded at 133.2ºC, and it possesses a refractive index of 1.536, signifying stability under defined conditions. The compound's solubility in water is noted as slightly soluble (6.2 g/L at 25ºC), which is an important consideration for its handling and processing in various chemical reactions. Furthermore, stringent specifications such as loss on drying ≤2.0%, heavy metals ≤10 ppm, water content ≤1.0%, sulphated ash ≤0.5%, and total impurities ≤0.5% underscore its high quality standards. These detailed specifications are vital for any enterprise seeking a Methyl 2-cyanoisonicotinate manufacturer in China.
The primary application driving the demand for Methyl 2-cyanoisonicotinate is its function as a key intermediate in the production pathway of Topiroxostat. Topiroxostat, a xanthine oxidase inhibitor, is a vital medication for managing elevated uric acid levels, commonly associated with gout. The synthesis of Topiroxostat relies heavily on the purity and structural integrity of Methyl 2-cyanoisonicotinate. Beyond this crucial role, its versatile structure allows for its potential use in the synthesis of other biologically active molecules, including certain tetra-substituted imidazolines that act as neuropeptide Y (NPY) Y5 receptor antagonists. This versatility increases its value in drug discovery and development.
For companies in need of a reliable CAS 94413-64-6 supplier in China, understanding these properties and applications is essential. Partnering with a reputable Methyl 2-cyanoisonicotinate manufacturer ensures consistent quality and supply chain reliability, critical factors for successful pharmaceutical production.
Perspectives & Insights
Alpha Spark Labs
“The physical and chemical properties of Methyl 2-cyanoisonicotinate are crucial for its effective application.”
Future Pioneer 88
“2 g/L at 25ºC), which is an important consideration for its handling and processing in various chemical reactions.”
Core Explorer Pro
“These detailed specifications are vital for any enterprise seeking a Methyl 2-cyanoisonicotinate manufacturer in China.”