In the realm of fine chemicals and pharmaceutical intermediates, a deep understanding of a compound's properties is fundamental for its effective utilization. Methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate, identified by its CAS number 334952-07-7, is one such compound that plays a crucial role in the synthesis of vital pharmaceutical products. This article aims to provide a comprehensive overview of its chemical characteristics, physical attributes, and primary applications, highlighting why it is a sought-after material for manufacturers and researchers.

Chemically, Methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate is known by several synonyms, including Methyl 4-((6-fluoro-2-quinoxalinyl)oxy)phenoxy)propanoate and others, reflecting its complex structure. Its molecular formula is C11H11NO6, and it has a molecular weight of approximately 253.20800 g/mol. The presence of a nitro group and ester functionalities within its structure makes it a versatile intermediate for various organic synthesis reactions.

From a physical standpoint, the compound typically presents as a light yellow powder. While specific melting point data is not always readily available, its physical state at room temperature is a key identifier for procurement. Properties such as density (approximately 1.3±0.1 g/cm³) and flash point (around 162.6±27.1 °C at 760 mmHg) offer important insights for handling, storage, and safety protocols. The refractive index is also noted as 1.543, providing further characterization data for quality control. These physical and chemical parameters are crucial for product specification sheets and for ensuring batch-to-batch consistency, which is paramount when purchasing from a chemical supplier.

The most significant application of Methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate is its indispensable role as an intermediate in the synthesis of Nintedanib and Nintedanib esylate. Nintedanib is a critical therapeutic agent used globally for treating serious medical conditions. Consequently, any manufacturer involved in the production of Nintedanib must secure a reliable source for this intermediate. The demand for high-purity intermediates like this one directly influences the efficiency and cost of producing the final drug product. Therefore, sourcing from manufacturers who can provide consistent quality, such as those in China, becomes a strategic advantage for pharmaceutical companies.

For businesses looking to buy Methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate, understanding the specifications is key. Purity levels are typically specified as ≥98% or, as seen in some test results, around 95.0% or 95.27%. It is advisable for buyers to request detailed analytical data, including HPLC or GC reports, to confirm the purity and identify any potential impurities. Additionally, packaging requirements, such as 25kg cardboard drums, and recommended storage conditions (cool, dry, well-closed container, away from moisture and strong light/heat) should be clearly communicated and adhered to by the supplier.

In summary, Methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate is more than just a chemical compound; it is a foundational element in the production of life-changing medications. Its well-defined properties and critical role in Nintedanib synthesis make it a high-value pharmaceutical intermediate. For manufacturers and researchers, engaging with established chemical manufacturers and suppliers ensures access to this essential compound, paving the way for continued advancements in pharmaceutical development and patient care.