N-Acetylsulfanilyl Chloride, identified by its CAS number 121-60-8, is a chemical compound of significant industrial importance, particularly within the pharmaceutical and dye sectors. As a key intermediate, its properties, synthesis routes, and market dynamics are crucial for anyone involved in its procurement or utilization. This article aims to provide a comprehensive overview for professionals seeking to buy or understand this compound.

Chemically, N-Acetylsulfanilyl Chloride is an off-white to slightly grey granular crystalline powder. Its molecular formula is C8H8ClNO3S, with a molecular weight of 233.67 g/mol. It is known to be slightly soluble in common organic solvents like acetonitrile, chloroform, and DMSO, and is sensitive to moisture, requiring careful handling and storage. The compound's melting point typically falls between 142-145 °C (with decomposition), indicating its stability under controlled conditions. These physical and chemical properties are vital for researchers and formulators when assessing its suitability for specific applications.

The synthesis of N-Acetylsulfanilyl Chloride commonly involves the reaction of acetanilide with chlorosulfuric acid at controlled temperatures. This process, when optimized, yields the desired product with high purity. Understanding the manufacturing process is beneficial for buyers who wish to vet their suppliers and ensure the quality of the chemical intermediate. Market insights often reveal that manufacturers in China are leading suppliers, offering competitive pricing and substantial production capacities. This makes inquiries like 'N-Acetylsulfanilyl Chloride price' or 'reliable manufacturer of CAS 121-60-8' common among global buyers.

The primary use of N-Acetylsulfanilyl Chloride is as an intermediate in the synthesis of sulfanilamide and its derivatives, which are fundamental to the production of sulfa drugs. These drugs are essential for treating various bacterial infections. Additionally, its utility extends to the synthesis of certain dyes, highlighting its versatility. For professionals looking to source this chemical, identifying a dependable supplier that can guarantee consistent quality and timely delivery is paramount.

Market trends indicate a steady demand for N-Acetylsulfanilyl Chloride, driven by the ongoing need for sulfa-based pharmaceuticals and specialty chemicals. Buyers often seek direct suppliers or manufacturers to ensure better pricing and direct communication regarding product specifications. Engaging with suppliers who provide clear documentation, such as Material Safety Data Sheets (MSDS) and Certificates of Analysis (CoA), is a standard practice for ensuring product integrity and compliance.

In conclusion, N-Acetylsulfanilyl Chloride (CAS 121-60-8) is a key intermediate with diverse applications. By understanding its properties, synthesis, and market landscape, professionals can make informed decisions when sourcing this essential chemical from reputable manufacturers and suppliers.