For professionals in the chemical and pharmaceutical industries, a thorough understanding of key intermediates is crucial for efficient research and development. N-Boc-N-methylethanolamine, identified by CAS number 57561-39-4, is a compound that has garnered significant attention due to its utility in complex organic synthesis. This article aims to provide a detailed overview of its properties, common synthesis pathways, and essential handling information, thereby aiding researchers and procurement specialists in their sourcing and application endeavors.

N-Boc-N-methylethanolamine is a derivative of ethanolamine, featuring a tert-butoxycarbonyl (Boc) group attached to the nitrogen atom and a methyl group also on the nitrogen. Its molecular formula is C8H17NO3, with a molecular weight of approximately 175.23 g/mol. Typically, it appears as a clear, light yellow liquid. Key physical properties include a density of around 1.037 g/cm³, a boiling point of 120-126 °C at 4 mmHg, and a flash point of 102.1 °C. It exhibits solubility in common organic solvents such as dichloromethane and methanol, while having limited solubility in water.

The synthesis of N-Boc-N-methylethanolamine is commonly achieved through the reaction of 2-(methylamino)ethanol with di-tert-butyl dicarbonate (Boc anhydride). This reaction is typically carried out in an organic solvent like dichloromethane at room temperature. The Boc anhydride selectively reacts with the secondary amine group, introducing the protective Boc moiety. Following reaction completion, standard work-up procedures involving extraction and drying yield the desired product. This synthetic route is generally efficient, providing high yields of the target compound. For those looking to buy N-Boc-N-methylethanolamine, understanding this synthesis process can inform quality expectations when evaluating different manufacturers or suppliers.

Safety and handling are critical when working with any chemical intermediate. N-Boc-N-methylethanolamine requires appropriate storage conditions, typically between 2-8°C, and should be kept in a tightly closed container in a cool, dry place to maintain its stability and purity. While specific hazard statements vary, general precautions for handling organic chemicals should always be followed, including wearing appropriate personal protective equipment (PPE) such as gloves, safety glasses, and lab coats. Proper ventilation is also recommended.

As a key intermediate, particularly in the synthesis of anticancer agents and other complex pharmaceutical molecules, N-Boc-N-methylethanolamine is a valuable asset for any research laboratory. Ensuring a reliable supply from a trusted supplier, ideally one with a strong presence as a manufacturer in China, guarantees access to high-purity material for your critical projects.