For chemists and researchers in the fine chemical and pharmaceutical industries, a deep understanding of key intermediates is essential for successful synthesis. N-Methyl-4-piperidinol (CAS 106-52-5) is one such compound, prized for its versatility and application in creating complex molecules. This article aims to provide a comprehensive overview of its properties, synthesis methods, and critical uses, empowering professionals to make informed decisions when seeking to procure this vital chemical.

N-Methyl-4-piperidinol, known by its IUPAC name 1-methylpiperidin-4-ol, is a hydroxylated piperidine derivative. Its key physical properties include a melting point typically between 29-31 °C, meaning it can exist as a liquid after melting at room temperature. With a boiling point around 200 °C and a density of approximately 0.98 g/mL at 20 °C, it exhibits characteristics suitable for various chemical processes. The compound’s miscibility in water and its hygroscopic nature are also important considerations for handling and storage.

The synthesis of N-Methyl-4-piperidinol often involves the reduction of N-methyl-4-piperidone. Various catalytic hydrogenation methods can be employed, often utilizing specialized catalyst complexes and hydrogenation reagents under controlled temperature and pressure. Detailed procedures, including purification via silica gel chromatography or preparative thin-layer chromatography, ensure the attainment of high purity levels, which is crucial for its end applications. For those looking to buy N-Methyl-4-piperidinol, understanding these synthesis routes can help in evaluating the quality offered by a manufacturer.

The significance of CAS 106-52-5 lies primarily in its role as a reactant in advanced organic synthesis. It is instrumental in the development of pharmacologically active compounds, such as antitumor agents, where it aids in optimizing drug scaffolds. Furthermore, it is a key intermediate in the synthesis of histamine H4 receptor antagonists and various kinase inhibitors targeting pathways like VEGFR and FGFR. Researchers frequently order N-Methyl-4-piperidinol online for these specific applications in drug discovery.

As a dedicated N-Methyl-4-piperidinol manufacturer in China, we prioritize providing high-quality materials that meet the demanding standards of the pharmaceutical and fine chemical sectors. We offer competitive prices and a reliable supply chain, ensuring that you can efficiently procure this essential compound. We encourage R&D professionals and procurement managers to request a quote for N-Methyl-4-piperidinol and explore our capabilities as a premier chemical supplier.