In the realm of fine chemicals and pharmaceutical intermediates, O-(2-(vinyloxy)ethyl)hydroxylamine, identified by CAS number 391212-29-6, is a compound of significant interest. Possessing the molecular formula C4H9NO2 and a molecular weight of 103.12 g/mol, this molecule is valued for its dual functionality, featuring both a hydroxylamine group and a vinyl ether moiety. These structural attributes bestow upon it a unique reactivity profile, making it an indispensable intermediate in various synthetic applications, most notably in the pharmaceutical sector.

The chemical properties of O-(2-(vinyloxy)ethyl)hydroxylamine are key to its utility. Its physical form is typically described as a colorless to light yellow liquid or a white powder, depending on purity and storage conditions. With a reported boiling point of 60-65°C at 20 Torr and a density of 0.972 g/cm³, it exhibits characteristics common to many organic intermediates. The presence of the hydroxylamine group allows it to act as a nucleophile and participate in condensation reactions, while the vinyl ether group can undergo addition and substitution reactions. These properties make it a flexible building block for synthesizing more complex molecules.

The synthesis of O-(2-(vinyloxy)ethyl)hydroxylamine is primarily achieved through O-alkylation of hydroxylamine derivatives. A common method involves reacting 2-(2-(vinyloxy)ethoxy)isoindoline-1,3-dione with methylhydrazine in dichloromethane. This procedure, often conducted at room temperature and followed by purification via column chromatography, typically yields the compound in good purity. Manufacturers focus on optimizing these synthetic routes to ensure high yields and the absence of impurities, critical factors for its use in pharmaceutical manufacturing. The consistent supply of high-quality O-(2-(vinyloxy)ethyl)hydroxylamine is crucial for downstream applications.

The market significance of O-(2-(vinyloxy)ethyl)hydroxylamine is largely driven by its role as a pharmaceutical intermediate. Its application in the synthesis of antitumor agents like Selumetinib and Binimetinib highlights its importance in the development of advanced therapies. As research in oncology and other therapeutic areas progresses, the demand for such specialized intermediates is expected to remain strong. Reliable suppliers play a vital role in ensuring that this compound is readily available to meet the needs of the global pharmaceutical industry, supporting ongoing drug discovery and development efforts.