Orotic acid (CAS 65-86-1) is a fascinating molecule with a rich biochemical history and diverse applications, particularly in research and development. As a key intermediate in pyrimidine biosynthesis, its study offers insights into fundamental biological processes. For researchers and scientists seeking high-quality chemical reagents, understanding the properties and sourcing of Orotic acid is paramount. This article provides an overview of Orotic acid, its synthesis, chemical characteristics, and its utility in scientific research, emphasizing the importance of reliable suppliers like NINGBO INNO PHARMCHEM.

Chemical and Biological Significance of Orotic Acid
Orotic acid is a pyrimidinedione derivative and a carboxylic acid, appearing as a white, crystalline powder. Its molecular formula is C5H4N2O4, and it has a molecular weight of 156.10 g/mol. A distinguishing feature is its high melting point, exceeding 300°C, indicating significant thermal stability. Biologically, Orotic acid is a direct precursor to uracil, a fundamental RNA base, through a series of enzymatic steps. It is synthesized endogenously via dihydroorotate dehydrogenase, an enzyme crucial for the de novo synthesis of pyrimidines. This process is vital for DNA and RNA replication and repair, making Orotic acid a central player in cellular metabolism.

A buildup of Orotic acid in the body can lead to conditions like orotic aciduria, often associated with urea cycle disorders. This highlights its critical role in metabolic regulation. Furthermore, its ability to bind with metal ions has led to its use in forming mineral orotates, which are explored for their therapeutic potential in various health applications.

Synthesis and Research Utility
The synthesis of Orotic acid is an integral part of the pyrimidine biosynthesis pathway. Understanding this pathway allows researchers to investigate metabolic disorders, drug mechanisms, and cellular signaling. For laboratory use, Orotic acid serves as a standard reagent for studying enzyme kinetics, particularly orotate phosphoribosyltransferase (OPRT), which catalyzes the conversion of Orotic acid to orotidine-5'-monophosphate. This research is crucial for developing new therapeutic strategies targeting pyrimidine metabolism, such as in cancer chemotherapy.

Researchers also utilize Orotic acid to investigate its effects on cellular processes, including hepatic lipogenesis, cell signaling, and its potential role in conditions like hypertension and metabolic syndrome. The availability of high-purity Orotic acid from a trusted manufacturer is essential for the accuracy and reproducibility of these research findings.

Sourcing High-Purity Orotic Acid from NINGBO INNO PHARMCHEM
NINGBO INNO PHARMCHEM is a dedicated manufacturer and supplier of high-quality chemical compounds, including Orotic acid (CAS 65-86-1). We provide researchers with a reliable source of this essential biochemical, ensuring purity levels that meet stringent laboratory standards (≥99.0% assay). Our commitment to quality control and competitive pricing makes us an ideal partner for academic institutions and R&D departments. When you need to buy Orotic acid for your research, consider NINGBO INNO PHARMCHEM as your trusted supplier. We ensure consistent product quality and efficient delivery to support your scientific endeavors.