Pentafluorophenol, known by its CAS number 771-61-9, is a chemical compound that garners significant attention in research and industry due to its unique chemical structure and properties. This highly fluorinated aromatic alcohol presents as a white crystalline solid, typically with a purity exceeding 99%. Its stability and reactivity make it a versatile intermediate, particularly in fields such as pharmaceuticals, agrochemicals, and material science.

The presence of five fluorine atoms on the phenolic ring significantly influences the electronic properties of Pentafluorophenol. This fluorination enhances its acidity compared to phenol and makes it an excellent leaving group when converted into esters. These pentafluorophenyl esters are highly prized in organic synthesis, especially for activating carboxylic acids in peptide coupling reactions and for protein labeling. The efficiency and yield improvements achieved using these activated forms are substantial, making Pentafluorophenol a vital reagent for scientists and manufacturers.

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The applications of Pentafluorophenol extend beyond its role in peptide synthesis. It serves as a key intermediate in the development of fluorinated pharmaceuticals, enhancing their efficacy and bioavailability. In agrochemicals, it contributes to the synthesis of potent and stable crop protection agents. Furthermore, its unique properties are leveraged in material science for the creation of advanced polymers and liquid crystal materials.

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