Podophyllotoxin is a fascinating natural compound with a rich history and significant contemporary applications, particularly in the pharmaceutical and biomedical research sectors. Extracted from the roots and rhizomes of plants like *Podophyllum peltatum* (American mayapple) and *Sinopodophyllum hexandrum*, this lignan exhibits potent biological activities, most notably as an antimitotic agent. For professionals in drug discovery, formulation, and scientific research, understanding the properties and sourcing of Podophyllotoxin is key to leveraging its potential. We, as a leading manufacturer and supplier, are here to provide this essential information and a reliable supply.

Chemically, Podophyllotoxin (CAS 518-28-5) is a complex aryltetralin lignan characterized by a fused ring system and several oxygen-containing functional groups, including an alcohol, a lactone, and methoxy groups. Its structure contains four chiral centers, contributing to its specific biological interactions. While naturally occurring, its chemical synthesis is complex and less efficient than extraction from plant sources, making natural sourcing the primary method for obtaining this compound. It typically appears as a white to off-white powder and is soluble in organic solvents like chloroform and ethanol, but insoluble in water.

The medicinal applications of Podophyllotoxin are extensive and well-researched. Its primary mechanism of action involves binding to tubulin, destabilizing microtubules, and thereby inhibiting cell division. This makes it a powerful antimitotic drug. Historically, it has been used in topical treatments for viral infections such as molluscum contagiosum and external genital warts caused by HPV. In oncology, Podophyllotoxin and its derivatives, such as etoposide and teniposide, are critical chemotherapeutic agents used to treat a range of cancers by preventing cancer cell proliferation.

For researchers and manufacturers, the quality and source of Podophyllotoxin are paramount. Purity levels, typically verified by HPLC, are crucial for accurate experimental results and for meeting pharmaceutical grade standards. When looking to buy Podophyllotoxin, it's advisable to partner with reputable manufacturers and suppliers who can guarantee consistency, provide comprehensive documentation (like CoAs and SDSs), and offer competitive pricing, especially for bulk orders. Sourcing from China, a major hub for chemical production, can provide access to high-quality material at favorable prices.

The ongoing research into Podophyllotoxin continues to uncover new therapeutic potentials, including its use in combination therapies and the development of novel derivatives with improved efficacy and reduced toxicity. Its role as a natural product intermediate also makes it valuable in exploring phytochemistry and medicinal botany.

In summary, Podophyllotoxin is a critical natural compound with significant antiviral and anticancer properties, driven by its antimitotic activity. Understanding its chemical properties, diverse applications, and the importance of reliable sourcing is essential for any professional working in related fields. We are proud to be a trusted manufacturer and supplier of high-purity Podophyllotoxin, ready to support your research and development needs.