The successful execution of complex organic synthesis projects hinges on a deep understanding of the chemical properties of the starting materials and intermediates used. For researchers and chemists, grasping the nuances of compounds like 2-Fluoro-5-iodobenzoic acid (CAS: 124700-41-0) is essential for designing efficient and effective synthetic routes. As a provider of high-quality chemical intermediates, we aim to equip our clients with the knowledge they need.

2-Fluoro-5-iodobenzoic acid is characterized by its white solid appearance and a purity typically exceeding 98.0%. Its melting point falls within the range of 164-168°C, indicating a stable crystalline structure at room temperature. The boiling point of 324.7°C suggests a relatively low volatility, which is beneficial for handling and storage. A flash point of 150.2°C further contributes to its safety profile under standard laboratory conditions. These physical properties are critical for safe handling and process design.

However, it is the chemical reactivity of 2-Fluoro-5-iodobenzoic acid that makes it so valuable in organic synthesis. The molecule contains three key functional components:

1. Carboxylic Acid Group (-COOH): This acidic functional group readily undergoes esterification, amidation, and salt formation. It also serves as a reactive handle for further modifications or for directing regioselective reactions on the aromatic ring. Its presence also impacts the solubility profile, making it soluble in basic aqueous solutions.

2. Fluorine Atom (-F): The fluorine substituent is known for its high electronegativity and small atomic radius. When attached to an aromatic ring, it can significantly influence the electron density distribution, affecting the reactivity of other positions on the ring. Fluorine is also valued for its ability to enhance metabolic stability, lipophilicity, and binding interactions in biologically active molecules, making it a prized element in pharmaceutical and agrochemical design.

3. Iodine Atom (-I): The iodine atom is a larger, more polarizable halogen. Its primary utility in synthesis stems from its excellent leaving group ability in nucleophilic aromatic substitution reactions and its crucial role in a wide range of palladium-catalyzed cross-coupling reactions. Techniques like Suzuki-Miyaura, Heck, Sonogashira, and Buchwald-Hartwig couplings heavily rely on aryl iodides to efficiently form new carbon-carbon and carbon-heteroatom bonds. This makes 2-Fluoro-5-iodobenzoic acid a prime candidate for building complex molecular frameworks.

The interplay of these functional groups allows chemists to perform sequential transformations. For instance, one might first utilize the iodine for a cross-coupling reaction and then functionalize the carboxylic acid group, or vice versa, depending on the desired outcome. The position of these substituents on the benzene ring is also critical for directing regioselectivity in subsequent reactions.

As a manufacturer and supplier, we ensure that our 2-Fluoro-5-iodobenzoic acid meets stringent purity requirements, typically ≥98.0% assay and ≤0.2% moisture content. This level of purity is vital to avoid unwanted side reactions and ensure reproducibility in complex synthetic procedures. For those seeking to 'buy 2-Fluoro-5-iodobenzoic acid', understanding these properties allows for more informed decision-making regarding its application in their specific research or manufacturing goals.

In conclusion, the chemical properties of 2-Fluoro-5-iodobenzoic acid make it an exceptionally versatile and powerful intermediate in organic synthesis. Its trifunctional nature, combined with the unique influence of fluorine and iodine, offers synthetic chemists a rich platform for molecular innovation. We are proud to supply this critical compound, enabling advancements across scientific disciplines.