Understanding the Properties of 3-Fluoro-2-nitropyridine for Synthesis
For chemists engaged in organic synthesis, understanding the specific properties of intermediate compounds is key to successful reaction design and product development. 3-Fluoro-2-nitropyridine (CAS 54231-35-5) is one such compound, valued for its unique structural features and reactivity, making it a sought-after building block in both academic research and industrial applications, particularly within the pharmaceutical and agrochemical sectors.
The molecular structure of 3-Fluoro-2-nitropyridine is characterized by a pyridine ring, which is an aromatic six-membered heterocycle containing one nitrogen atom. Attached to this ring are two key functional groups: a fluorine atom at the 3-position and a nitro group (-NO2) at the 2-position. This specific arrangement of substituents confers several important properties. The electronegativity of the fluorine atom and the electron-withdrawing nature of the nitro group significantly influence the electronic distribution within the pyridine ring, activating certain positions for nucleophilic attack.
Physically, 3-Fluoro-2-nitropyridine is typically described as a yellow to light brown low melting solid, with reported melting points in the range of 30-38°C. This characteristic means it can exist as a solid or a liquid depending on ambient temperatures, which can influence its handling and dissolution in various solvents. Its molecular weight is approximately 142.09 g/mol. The purity of this intermediate is often critical, with specifications commonly set at 98.0% or higher, as confirmed by methods like HPLC. Manufacturers often package it in drums to ensure stability and ease of transport.
The reactivity of 3-Fluoro-2-nitropyridine makes it an excellent substrate for a variety of synthetic transformations. The nitro group is known to activate the aromatic ring towards nucleophilic aromatic substitution (SNAr) reactions, particularly at positions ortho and para to it. In this case, the fluorine atom at the 3-position can be a leaving group, or the nitro group can be reduced to an amine, opening pathways for further derivatization through acylation, alkylation, or coupling reactions. This versatility makes it a valuable starting material for constructing more complex heterocyclic systems.
When planning to buy 3-Fluoro-2-nitropyridine, researchers often seek suppliers who can guarantee high purity and consistent batch-to-batch quality. Understanding these intrinsic properties helps scientists choose the right reaction conditions and predict outcomes, whether they are developing new drug candidates or formulating advanced crop protection agents. A reliable manufacturer will provide detailed product specifications and support, ensuring that procurement aligns with research and development objectives.
In essence, the distinct chemical and physical properties of 3-Fluoro-2-nitropyridine, stemming from its unique structural makeup, position it as a valuable and versatile intermediate for sophisticated organic synthesis. Its effective utilization relies on sourcing from dependable manufacturers who can supply it at the required purity levels.
Perspectives & Insights
Molecule Vision 7
“The purity of this intermediate is often critical, with specifications commonly set at 98.”
Alpha Origin 24
“Manufacturers often package it in drums to ensure stability and ease of transport.”
Future Analyst X
“The reactivity of 3-Fluoro-2-nitropyridine makes it an excellent substrate for a variety of synthetic transformations.”