For any chemist or materials scientist, a thorough understanding of a compound's properties is fundamental to its successful application. 6-Fluoroindole-2-carboxylic acid (CAS 3093-97-8) is a significant chemical intermediate, and knowing its characteristics is key to leveraging its full potential. This article outlines the essential physical and chemical properties of this valuable fluorinated indole derivative.

Chemical Identity and Structure

6-Fluoroindole-2-carboxylic acid, with the molecular formula C9H6FNO2 and a molecular weight of 179.15 g/mol, is characterized by an indole ring system that has a fluorine atom substituted at the 6th position and a carboxylic acid group at the 2nd position. The CAS number 3093-97-8 uniquely identifies this compound.

Physical Characteristics

  • Appearance: Typically described as a light yellow to yellow or orange powder, often presenting as crystals. The precise color and form can depend on the purity and manufacturing process.
  • Purity: High purity is critical for synthesis. Specifications commonly indicate purity levels of ≥98.0% or ≥98% (by HPLC), ensuring reliability in downstream applications.
  • Melting Point: It has a relatively high melting point, often cited around 244-250 °C (with decomposition), indicating good thermal stability in its solid form.
  • Solubility: While specific solubility data may vary, indole derivatives with carboxylic acid groups generally exhibit moderate solubility in polar organic solvents and can be soluble in basic aqueous solutions due to salt formation.

Chemical Properties and Reactivity

  • Acidity: The carboxylic acid group imparts acidic properties, with a predicted pKa around 4.38 ± 0.30. This acidity allows for salt formation and participation in esterification, amidation, and other related reactions.
  • Zwitterionic Nature: The presence of both a secondary amine in the indole ring and a carboxylic acid group allows the molecule to exist in a zwitterionic form. This internal proton transfer can influence its spectroscopic properties, such as fluorescence emission bands.
  • Light Sensitivity: Some sources indicate it is light-sensitive, suggesting that storage in amber containers or protected from light is advisable.
  • Synthetic Versatility: As an intermediate, its primary value lies in its reactivity. The carboxylic acid can be modified, and the indole ring can undergo further functionalization, making it a versatile building block for complex organic molecules.

Importance for Procurement and Research

Understanding these properties is vital for procurement managers and researchers. When you buy 6-fluoroindole-2-carboxylic acid, you need to ensure it meets the purity standards for your intended application. NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated supplier committed to providing high-quality chemical intermediates. We provide detailed specifications and technical data to support your research and development needs. Contact us to source this essential compound with confidence.