For chemists and researchers engaged in organic synthesis and pharmaceutical development, a thorough understanding of key chemical intermediates is crucial. 2-Chloro-5-hydroxypyrimidine (CAS:4983-28-2) is one such compound, recognized for its versatile reactivity and significant role in various synthetic pathways. This article aims to provide a detailed overview of its properties, applications, and the considerations for procuring it from reliable sources.

2-Chloro-5-hydroxypyrimidine, with the molecular formula C4H3ClN2O and a molecular weight of approximately 130.53 g/mol, is typically encountered as an off-white to light brown solid. Its melting point is reported in the range of 195-196 °C, indicating its stability under standard laboratory conditions. Proper storage, usually under an inert atmosphere (like nitrogen or argon) at refrigerated temperatures (2-8°C), is recommended to maintain its integrity and purity. These physical characteristics are vital for handling and storage protocols in research and manufacturing settings.

The primary application of 2-Chloro-5-hydroxypyrimidine lies in its function as a pharmaceutical intermediate. It is a key building block for the synthesis of tandospirone derivatives, which are compounds investigated and used for their anxiolytic properties. This means that for drug discovery programs targeting anxiety and related neurological conditions, this intermediate is of significant interest. Researchers might seek to buy this compound using search terms like 'pharmaceutical intermediate 4983-28-2' or 'heterocyclic building block manufacturer'.

Beyond its specific role in anxiolytic synthesis, the structural features of 2-Chloro-5-hydroxypyrimidine – the pyrimidine ring, the chlorine atom, and the hydroxyl group – offer diverse opportunities for further chemical transformations. This makes it a valuable reagent for academic and industrial research in areas such as agrochemicals, material science, and the development of novel organic compounds. When exploring these possibilities, sourcing from a dependable supplier is paramount to ensure the quality required for intricate research projects.

For professionals looking to procure 2-Chloro-5-hydroxypyrimidine, engaging with manufacturers and suppliers who emphasize product quality, provide detailed technical data sheets, and offer responsive customer service is highly recommended. Whether for research purposes or larger-scale production, understanding the compound's properties and applications empowers better purchasing decisions and supports successful synthetic endeavors.