In the realm of fine chemicals and organic synthesis, understanding the precise properties of key intermediates is fundamental to successful research and manufacturing. 3',5'-Difluoroacetophenone, identified by CAS number 123577-99-1, is one such compound that offers unique advantages due to its specific chemical structure and physical characteristics. This article explores its defining attributes and widespread applications, providing insight for procurement managers and R&D scientists.

Chemically, 3',5'-Difluoroacetophenone is an aromatic ketone distinguished by two fluorine atoms symmetrically positioned on the benzene ring. This fluorination significantly impacts its electronic and physical properties compared to its non-fluorinated counterparts. The presence of fluorine can enhance thermal stability, alter solubility, and influence reactivity, making it a highly sought-after building block. Its molecular formula is C8H6F2O, with a molecular weight of approximately 156.13 g/mol. Physically, it is typically described as a white to light yellow solid with a low melting point, often in the range of 34-38°C, suggesting it can be handled as either a solid or a molten liquid depending on ambient temperatures. Its boiling point is around 94°C at standard pressure, and it possesses an index of refraction of 1.4876.

The primary utility of 3',5'-Difluoroacetophenone lies in its role as an intermediate for organic synthesis. Its structure makes it an invaluable component in the creation of complex molecules, particularly within the pharmaceutical and agrochemical industries. Researchers frequently buy this compound to synthesize novel drug candidates, where the fluorine atoms can modulate pharmacokinetic and pharmacodynamic properties. In agrochemical development, it contributes to the creation of more potent and stable active ingredients.

For businesses looking to purchase 3',5'-Difluoroacetophenone, understanding its specifications, such as an assay of ≥98.0%, is critical. Identifying reliable manufacturers and suppliers is key to ensuring consistent quality and availability. When seeking to buy, inquire about packaging options (e.g., 25 kg/drum) and storage conditions (cool, ventilated place) to maintain product integrity. The availability of this intermediate from reputable suppliers in regions like China ensures that chemical professionals have access to the materials needed for cutting-edge research and production.