For researchers and procurement specialists in the pharmaceutical sector, a thorough understanding of chemical intermediates is vital. (E)-3-(4-Amino-3,5-dimethylphenyl)acrylonitrile Hydrochloride (CAS: 661489-23-2) is a prime example, recognized for its critical role in the synthesis of the antiretroviral drug Rilpivirine. This article focuses on the key physical and chemical properties of this compound, providing insights valuable for R&D scientists and product formulators looking to purchase this essential material.

Chemical Identity and Structure

(E)-3-(4-Amino-3,5-dimethylphenyl)acrylonitrile Hydrochloride has the molecular formula C11H13ClN2 and a molecular weight of approximately 208.69 g/mol. Its structure features a phenyl ring substituted with two methyl groups and an amino group, attached to an acrylonitrile moiety via an ethene linkage in the (E) configuration. The hydrochloride salt form contributes to its stability and handling characteristics, making it suitable for industrial chemical processes.

Physical Appearance and Purity

A defining characteristic of this pharmaceutical intermediate is its physical appearance: a light green crystalline powder. This visual cue often indicates a well-controlled synthesis process. Crucially, the compound is typically supplied with a high assay, meaning its purity level is generally ≥98.0%. This high degree of purity is indispensable for pharmaceutical applications, as it minimizes the presence of impurities that could interfere with subsequent reactions or compromise the efficacy and safety of the final API, Rilpivirine. For R&D scientists, sourcing materials with guaranteed purity levels like this is key to successful experimental outcomes.

Key Properties for Handling and Storage

Understanding the properties of (E)-3-(4-Amino-3,5-dimethylphenyl)acrylonitrile Hydrochloride is essential for optimal usage and storage. While detailed solubility data might vary, it is generally expected to be soluble in common organic solvents used in chemical synthesis. From a practical standpoint for procurement managers, typical packaging involves 25 kg drums, though custom packaging solutions are often available from specialized suppliers in China. Proper storage conditions are critical to maintain its integrity; it is usually recommended to store the material in a cool, well-ventilated place, protected from moisture and direct sunlight. This ensures its stability and readiness for use in API manufacturing.

Significance in Pharmaceutical Applications

The primary application of (E)-3-(4-Amino-3,5-dimethylphenyl)acrylonitrile Hydrochloride is as an intermediate in the synthesis of Rilpivirine. Its specific reactivity and structural features make it an ideal precursor for building the complex molecular architecture of this important antiretroviral drug. Pharmaceutical companies looking to buy this intermediate should prioritize suppliers who can consistently deliver material that meets these precise specifications. The availability of such high-quality building blocks directly impacts the efficiency and cost-effectiveness of producing essential medications.

In summary, the light green crystalline powder form, high purity of ≥98.0%, and its specific role as a Rilpivirine intermediate are the defining features of (E)-3-(4-Amino-3,5-dimethylphenyl)acrylonitrile Hydrochloride. For research scientists and formulation experts, understanding these properties is crucial for effective sourcing and utilization. When seeking to purchase this compound, partnering with a reputable manufacturer known for quality and reliability is the best approach to ensure project success.